As shown, the mice that received lyral had much fewer newborns than the control mice treated with PBS, showing that lyral has a strong negative impact on procreation. This indicates that the ORs at the sperm surface are biologically active and make an important contribution to r...
None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev. Biol.2003;... ZY...
Progesterone, primarily recognized as a female steroid hormone, is reported to affect several sperm functions especially capacitation, motility and acrosome reaction. These effects of progesterone on the spermatozoa are mediated via the progesterone binding sites/progesterone receptor (PR) on the acrosomal...
Identify the hormone from the given action: Stimulates egg and sperm formation in ovaries and testes. What are the receptor types and neurotransmitters in the three systems? For the hormone calcitonin (in humans) what is the: 1. origin (gland that secretes the hormone) 2. action of the hor...
Angiotensin receptors with atypical binding properties for the known AT1- and AT2-specific ligands are expressed on human cardiac fibroblasts and in the human uterus. In several animal models, receptors with high affinity for angiotensin (1–7) have been described. AT1 stimulation is mediated by ...
Nuclear receptors (NRs) contain a large superfamily of at least 48 DNA-binding transcription factors whose target genes are critical for many biological processes, including growth, differentiation, development, and metabolism [1,2]. The NR superfamily, sharing common structure, can be divided into ...
Two other closely related genes which are highly expressed in the brain have subsequently been identified in mammals, trkB (Klein et al., 1989) and trkC (Lamballe et al., 1991), and found to encode for proteins binding BDNF, NT-4/5 and NT-3 (Klein et al., 1991b; Lamballe et al....
P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate (ATP). For years their functional significance was... Khakh,S Baljit,North,... - 《Nature》 被引量: 1041发表: 2006年 Crystal structure of the ATP-gated P2X(4) ion channel in the closed...
Therefore, non-genomic pathways are possibly engaged in RAR and RXR modulation during RA-mediated differentiation of SH-SY5Y cells. Protein degradation of retinoid receptors induced by proteasome can exert multiple functions for RA signaling pathways, but its exact role is yet not clear. It might ...
Although speculated for decades prior, CK were first isolated in in the 1950s from autoclaved salmon sperm DNA and then from plant tissue cultures (Skoog and Miller1957). There are several forms of CK, including the synthetic kinetin, discovered from the salmon, as well as naturally occurring ...