RTKs是最大的一类酶联受体,它既是受体,又是酶,能够同配体结合,并将靶蛋白的酪氨酸残基磷酸化。所有的RTKs都是由三个部分组成的:含有配体结合位点的细胞外结构域、单次跨膜的疏水α螺旋区、含有酪氨酸蛋白激酶(RTK)活性的细胞内结构域。 已发现50多种RTKs,主要的几种类型包括:①表皮生长因子受体;②血小板生长...
受体酪氨酸激酶(receptor tyrosine kinase, RTK) 是细胞膜表面受体的一类,是一类胞质结构域具有蛋白酪氨酸激酶功能的细胞表面受体,这类受体本身兼具受体和酪氨酸激酶两种功能。当这类受体与配体结合后可催化自身或底物蛋白的酪氨酸残基磷酸化,激活后的蛋白质进一步催化细胞内的一系列反应,从而把细胞外信号传递到细胞内。
Receptor Tyrosine Kinase (RTK) Background Receptor tyrosine kinases (RTKs)are essential components of signaling transduction that mediate cell-to-cell communication. The RTK family includes, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptors (PDGFR), fibroblast growth factor...
Receptor tyrosine kinases (RTK) form a family of transmembrane proteins widely conserved in Metazoa, with key functions in cell-to-cell communication and control of multiple cellular processes. A new family of RTK named Venus Kinase Receptor (VKR) has been described in invertebrates. The VKR ...
Receptor tyrosine kinases are a diverse group of transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinase (RTK) is part of the larger family of protein tyrosine kinase. Receptor tyrosine kinases have been shown to pla...
The Ror family of receptor tyrosine kinases (RTKs) are originally identified as orphan receptor tyrosine kinases whose tyrosine kinase domains are highly similar to those of the Trk family of RTKs. They exhibit evolutionarily conserved structure in inver
receptor tyrosine kinase, RTKs (受体酪氨酸激酶) 答案:RTKs是最大的一类酶联受体,它既是受体,又是酶,能够同配体结合,并将靶蛋白的酪氨酸残基磷酸化。所有的RTKs都是由三个... 点击查看完整答案 你可能感兴趣的试题 名词解释 calmodulin (钙调蛋白) 答案:是真核生物细胞中的胞质溶胶蛋白,由148个氨基酸组成...
Receptor tyrosine kinases (RTKs) are a family of cell surface receptors with an intracellular domain that has tyrosine kinase activity (Fig. 26.2). They mediate a host of cellular programs including cell proliferation, cell differentiation, cell death and inflammation. Ligands for RTKs include cy...
Receptortyrosinekinases (RTKs) are a large family ofcell surface receptorswhich are involved in keycellular processessuch ascell proliferation, differentiation, survival and metabolism. Upon binding of a specific ligand, receptordimerizationis induced, and the activated kinase inducesautophosphorylationof the...