The c-MET (hereafter referred as MET) receptor tyrosine kinase was originally identified as the cellular homologue of the TPR-MET oncoprotein. MET can be overcxprcsscd in a number of malignancies, sometimes mutated (germline mutations/single nucleotide polymorphisms [SNPs] or somatic mutations), ...
Receptor tyrosine kinases (RTKs) are increasingly recognized as having the capacity to signal post-internalization. Signalling outputs and/or duration, and subsequent cellular outcome, are thought to be distinct when emanating from endosomes compared wit
The tyrosine kinase Met, the product of the c-met proto-oncogene and the receptor for hepatocyte growth factor/scatter factor (HGF/SF), mediates signals critical for cell survival and migration. The human pathogen Listeria monocytogenes exploits Met signaling for invasion of host cells via its sur...
Targeting Receptor Tyrosine Kinase MET in Cancer: Small Molecule Inhibitors and Clinical Progress MET (MNNG HOS transforming gene) is one of the receptor tyrosine kinases whose activities are frequently altered in human cancers, and it is a promising th... JJ Cui - 《Journal of Medicinal Chemistr...
Muscle-specific tyrosine kinase;MET,EPHA, Ephrin-A;MEN2,LMR, Lemur kinase; Multiple endocrine neoplasia type 2;NSCLS, Non-small cell lung cancer;NTRK, Neurotrophic tyrosine kinase;PNS, Peripheral nervous system;RET, Rearranged during transfection tyrosine kinase;ROR, Receptor tyrosine kinase-like ...
[92]. RTK amplifications also act as an avenue for tumor cells to escape therapeutic treatment. For example,METamplification andHER2amplification can be detected inEGFR-mutant lung cancers that become resistant to EGFR tyrosine kinase inhibitor therapy [93]. RTK overexpression is represented ...
Discovery of N-(4-(2- amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl )-2-oxo-1,2-dihy- dropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. J Med Chem 2009; 52: 1251–1254. 50. Heeb MJ, ...
We investigated the MET receptor tyrosine kinase as a novel target for the treatment of head and neck squamous cell carcinoma (HNSCC). MET/phosphorylated MET and HGF expression was analyzed in 121 tissues (HNSCC/normal) by immunohistochemistry, and in 20 HNSCC cell lines by immunoblotting. The ...
Novel receptor tyrosine kinase protein and isoforms thereof which are expressed in cells of the endothelial lineage, and DNA segments encoding the novel protein and isoforms thereof are disclosed. Methods for identifying ligands which are capable of binding to the receptor protein and methods for scree...
中文名称:人受体酪氨酸激酶C-MET(C-MET)ELISA试剂盒 中文同义词:人受体酪氨酸激酶C-MET(C-MET)ELISA试剂盒 英文名称:Human receptor tyrosine kinase C-MET (C-MET) ELISA kit 英文同义词: CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: ...