This kit is intended to be used for determination the level of RTP4 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.Cat.No: MBS...
(site 3 cleavage), releasing the intracellular domain (ICD), which translocates to the nucleus. In the nucleus, the ICD of Notch can bind to members of the CSL family of transcriptional repressors, and in the presence of CSL-binding protein (CBP) and mastermind-like protein-1 (MAML), ...
Transferrin is an iron-transporting glycoprotein found in the blood. When the protein is not bound with iron, it is called apotransferrin and will not bind with a transferrin receptor at physiological pH. Once iron is bound, however, apotransferrin will undergo a conformation change that will ...
Here, we report the finding of a novel receptor, low-density lipoprotein receptor-related protein 1 (LRP1), that is expressed on the BLB, as a potential target for shuttling therapeutics across this barrier. As a proof-of-concept, we developed an LRP1-binding peptide, IETP2, and ...
Interaction with PDZK1 Is Required for Expression of Organic Anion Transporting Protein 1A1 on the Hepatocyte Surface Although many organic anion transport protein (Oatp) family members have PDZ consensus binding sites at their C termini, the functional significance is unk... Wang,P. - 《Journal ...
The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing l
Due to this feature of the G-protein coupled receptor family, it should be considered whether this receptor family could harbour putative cargo receptors expressed in BECs, which could be harnessed for therapeutic delivery to the brain. Much effort has been put into identifying novel brain ...
The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of a bacterial hemoglobin receptor protein, nucleic acid encoding such a protein, recombinan...
Endothelial Protein C Receptor (EPCR) is a cell surface receptor that binds to Protein C, facilitating its activation by thrombin. EPCR plays a crucial role in transporting Activated Protein C (APC) across the blood-brain barrier and initiating cytoprotective signaling pathways. ...
The main structural proteins of caveolae are members of the caveolin gene family, caveolin-1, caveolin-2 and caveolin-3. Morphologically defined caveolae can be formed by the expression of caveolin-1, which is a small integral membrane protein, whose 34 hydrophobic amino acids inserted into the ...