COOKE, D. T.: ' Transport and Receptor Proteins of Plant Membranes: Molecular Structure and Function ', 1992, PLENUM PRESSWhite, I.R., Wise, A., Finan, P.M., Clarkson, J. and Millner, P.A. (1992) in: Transport and receptor proteins of plant membranes, (Cooke, D.T. and ...
Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facilitates cargo import, whereas remodelling into a retrograde train at the ciliary tip enables cargo ...
These experiments provide the first evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, for this new type of cell-surface receptor. 展开 关键词: Animals Cercopithecus aethiops Humans COS Cells Vitamin A Membrane Proteins Amino Acid Substitution Protein Structure...
a, TRAM engaging GR and FKBP12. b, c Unlinked warhead controls for GR-based TRAMs. 8 binds to GR and 9 binds to FKBP12. d, Nuclear hormone receptor (ERα, GR) hijacking for import of target proteins. e, Nuclear localization of mCherry-FKBP12 after treatment with 6 or unlinked warhea...
Receptors, Cytoplasmic and NuclearRepressor ProteinsLigandsTranscription, GeneticProtein Structure, TertiaryRev-erbβ is a heme-binding nuclear hormone receptor ... N Gupta,SW Ragsdale - 《Journal of Biological Chemistry》 被引量: 98发表: 2011年 Growth inhibitory retinoid effects after recruitment of re...
Importantly, we uncover that the expression of a set of transport proteins is modulated in a disease-dependent manner in 3xTgAD mice and in human sporadic AD brains. This study highlights molecular mechanisms underlying mitochondrial transport defects in AD that likely contribute to mitophagy failure...
Das and co-workers have shown that the N232Q mutation in PPT1 has the greatest effect on M6P-receptor binding. Therefore, we also analyzed the intracellular localization of the glycosylation mutated proteins in transfected COS-1 cells by immunofluorescence analysis. As suggested by the enzyme ...
Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide We investigated the import and sorting pathways of cytochrome b 2 and cytochrome c 1, which are functionally located in the intermembrane space of mitochon...
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic compartments. In humans, approximately 60 proteins are ...
Axonal transport is the process whereby motor proteins actively navigate microtubules to deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is widely regarded as essential for nerve development, function and survival. Mutations in genes encoding key components of...