. Furthermore, these 44 DEGs were enriched in other interleukin signaling pathways, such as JAK-STAT, IL-12, IL-17, IL-23, TNF, chemokines (GPCR ligand binding) and PRRs, including RIG-I-like receptor and NOD signaling. Multistudy factor analysis of eligible33datasets (WBCs: Dix et al....
Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 2011;3:102–14. Article CAS PubMed PubMed Central Google Scholar Ampomah PB, Moraes LA, Lukman HM, Lim LHK. Formyl peptide ...
S4C–E). Notably, the genes induced by the infection were enriched in multiple immune activation pathways, including cytokine-cytokine receptor interaction (e.g., Il22, Tnfrsf9 and Clcf1), JAK-STAT signaling pathway (e.g., Stat3), and chemokine signaling pathway (e.g., Ccr7) (...
IL-2 and IL-15 share the same Jak1/Jak3 and Stat3/Stat5 signal transduction pathway mediated via the IL-2Rβ/γc complex.17,29 IL-2Rα binds IL-2 with low affinity but has a very short 13–amino acid cytoplasmic domain30 and cannot transduce a signal. Because of its rapid on-rat...
Moreover, although both EPO and IL-2 can activate STAT5, EPO activates JAK2, whereas IL-2 activates JAK1 and JAK3 (22). Therefore, STAT5 can be activated through different signal transduction pathways by different receptors (22). It has been suggested that the specific interactions between ...
(64C1385.1; Novus Biologicals). Fluorescence minus one staining with isotype antibodies served as the negative controls. Cells were incubated with antibodies at RT for 30 minutes. All samples were analyzed within 24 hours using an LSR Fortessa (BD Biosciences) and FlowJo software version 10.1 (...
JAK-STAT signaling17. We previously described IL7RA activating mutations in Ph-like BCP-ALL18. These mutations often introduce cysteine into the juxtamembrane domain resulting in dimerization of the receptor and constitutive signaling. Although attempted in the mouse, it is unclear if activation of ...
(CHI3L1, also known as YKL-40/BRP-39)10. This is a secreted glycoprotein of ~40 kDa in size, which has been implicated in inflammatory diseases, tissue remodeling, and cancer progression11. IL-13/IL-13Rα2 interaction does not lead to activation of the JAK/STAT6 pathway; thus, it ...
While it is known that the interaction of IFNγ-R1 and JAK1 is essential for the signaling functionality of the IFNγ receptor complex50,51, a potential role of JAK1 in stabilizing IFNγ-R1 levels, and by extension the IFNγ receptor complex, has not been reported. We first investigated ...
tested the involvement of the JAK/STAT. We focused on this pathway because, first JAK/STAT comprises the major positive regulatory pathway for the induction of astrogliogenesis33,34, and second NR5A2 is negatively regulated by this pathway (Fig. 2a,b,i–n). In agreement, the expression of...