S4C–E). Notably, the genes induced by the infection were enriched in multiple immune activation pathways, including cytokine-cytokine receptor interaction (e.g., Il22, Tnfrsf9 and Clcf1), JAK-STAT signaling pa
showing the phosphorylation of JAK1, JAK2 and JAK3 in total ILC3s from siLPs of indicated mice on day 5 post theC. albicansinfection (H). Quantification of MFI (I,Rorc-cre–Fcer1gf/f,n = 5 mice;Rorc-cre+Fcer1gf/f,n = 4 mice). Data are representative of two (C–G...
The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002; 277: 33509–17. 3 Syrovets T, Jendrach M, Rohwedder A, Schule A, Simmet T. Plasmin- induced ...
(Stat) proteins, in particularStat5. The inter actions of the activated Stat proteins with DNAbinding sitesunderlies the specificity of the genomic effects of PRL. Signaling via the mitogen-activated protein kinase (MAPK) pathway has also been identified and an inter action with theepidermal ...
45,46,47,48 In addition, gene set enrichment analysis demonstrated that genes involved in pathways such as the inflammatory response, JAK-STAT as well as TNF-α signaling were down-regulated in monocytes upon IVIg priming in vivo (Figures 4C and 4D). Of note, in Dectin-1- as well as ...
Interaction of such extracellular signaling molecules with EGFR results in several activated intracellular cascades such as RAS/MAPK(ERK), PI3K/AKT/mTOR, and JAK/ STAT, thereby promoting proliferation, apoptosis inhibi tion, and cell survival [2, 3]. Involvement of EGFR in carcinogenesis as well ...
JAK-STAT signaling17. We previously described IL7RA activating mutations in Ph-like BCP-ALL18. These mutations often introduce cysteine into the juxtamembrane domain resulting in dimerization of the receptor and constitutive signaling. Although attempted in the mouse, it is unclear if activation of ...
However, a dose-dependent interference with signal transduction via the endogenous Ifnar complex was found for STAT1, STAT2, STAT3, Tyk2, and Jak1 activation, for gene induction, and for antiviral activity. In a similar approach, cells expressing the β1 chain of the interleukin-12 receptor ...
Moreover, although both EPO and IL-2 can activate STAT5, EPO activates JAK2, whereas IL-2 activates JAK1 and JAK3 (22). Therefore, STAT5 can be activated through different signal transduction pathways by different receptors (22). It has been suggested that the specific interactions between ...
EpoR activation stimulates tyrosine phosphorylation of several proteins, which impact upon multiple signaling pathways capable of promoting cell survival (Cheung et al. (2001) Nephron 87, 215-222). These include the activation of Jak-2, STAT-5, and the PI3K pathway. ...