. Furthermore, these 44 DEGs were enriched in other interleukin signaling pathways, such as JAK-STAT, IL-12, IL-17, IL-23, TNF, chemokines (GPCR ligand binding) and PRRs, including RIG-I-like receptor and NOD signaling. Multistudy factor analysis of eligible33datasets (WBCs: Dix et al....
S4C–E). Notably, the genes induced by the infection were enriched in multiple immune activation pathways, including cytokine-cytokine receptor interaction (e.g., Il22, Tnfrsf9 and Clcf1), JAK-STAT signaling pathway (e.g., Stat3), and chemokine signaling pathway (e.g., Ccr7) (...
However, a dose-dependent interference with signal transduction via the endogenous Ifnar complex was found for STAT1, STAT2, STAT3, Tyk2, and Jak1 activation, for gene induction, and for antiviral activity. In a similar approach, cells expressing the β1 chain of the interleukin-12 receptor ...
IL-2 and IL-15 share the same Jak1/Jak3 and Stat3/Stat5 signal transduction pathway mediated via the IL-2Rβ/γc complex.17,29 IL-2Rα binds IL-2 with low affinity but has a very short 13–amino acid cytoplasmic domain30 and cannot transduce a signal. Because of its rapid on-rat...
The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002; 277: 33509–17. 3 Syrovets T, Jendrach M, Rohwedder A, Schule A, Simmet T. Plasmin- induced ...
JAK-STAT signaling17. We previously described IL7RA activating mutations in Ph-like BCP-ALL18. These mutations often introduce cysteine into the juxtamembrane domain resulting in dimerization of the receptor and constitutive signaling. Although attempted in the mouse, it is unclear if activation of ...
Moreover, although both EPO and IL-2 can activate STAT5, EPO activates JAK2, whereas IL-2 activates JAK1 and JAK3 (22). Therefore, STAT5 can be activated through different signal transduction pathways by different receptors (22). It has been suggested that the specific interactions between ...
While it is known that the interaction of IFNγ-R1 and JAK1 is essential for the signaling functionality of the IFNγ receptor complex50,51, a potential role of JAK1 in stabilizing IFNγ-R1 levels, and by extension the IFNγ receptor complex, has not been reported. We first investigated ...
tested the involvement of the JAK/STAT. We focused on this pathway because, first JAK/STAT comprises the major positive regulatory pathway for the induction of astrogliogenesis33,34, and second NR5A2 is negatively regulated by this pathway (Fig. 2a,b,i–n). In agreement, the expression of...
pathway in salmonid cell lines [19,20,21,22,23]; activation of this pathway involves a general mechanism to induce the clearance of the viral infection. The IFN pathway triggers the synthesis of the IFN cytokines through janus kinase-signal transducer and activator of transcription (JAK-STAT)...