Nishimoto I, Ogata E, Okamoto T. Guanine nucleotide-binding protein interacting but unstimulating sequence located in insulin-like growth factor II receptor. Its autoinhibitory characteristics and structural determinants. J Biol Chem 1991; 266: 12747–12751. PubMedCASGoogle Scholar Kyte J, Doolittle ...
Given the necessity of the endolysosomal two-pore channel (TPC1 or TPC2) in NAADP signaling, we performed affinity purification and quantitative proteomic analysis of the interacting proteins of NAADP and TPCs. We identified a Sm-like protein Lsm12 complexed with NAADP, TPC1, and TPC2. Lsm12...
Interestingly, the exposure of cells to bivalent antibodies to the IR, but not the corresponding monovalent Fab fragments, has long been known to elicit various insulin-like responses31, suggesting that multivalent receptor activation can regulate cellular responses. Here we revisit this concept and ...
Initially described as a peripheral benzodiazepine receptor, translocator protein (TSPO) binds a variety of benzodiazepine-like drugs and is involved in cholesterol transport across the outer mitochondrial membrane in many tissues. It is a target for anxiety and neurological disorders (Nothdurfter et al...
Vehicle cream (286202303, lot 8H38; Vaseline; KENEI Pharmaceutical, Tokyo, Japan) was applied topically on the shaved back of mice from the control group according to the same schedule as the IMQ group. To assess the severity of psoriasis-like dermatitis, the clinical Psoriasis Area and ...
Fms-interacting protein FIRE: Fms-intronic regulatory element FL: FLT3 ligand flk-2: Fetal liver kinase 2 Flt3: Fms-like tyrosine kinase 3 FUS/TLS: Fused in sarcoma/translocated in sarcoma Fyn: Proto-oncogene tyrosine-protein kinase Fyn Gab2: Grb2-associated-binding protein 2 GCL...
like protein-2, Etbrlp2, Ebp2, Cns2 Follicle stimulating hormone receptor, Fsh-R, follitropin receptor G protein-coupled receptor G protein-coupled receptor Gpr1 G protein-coupled receptor, Acca orphan receptor G protein-coupled receptor 6 G protein-coupled receptor 7 G protein-coupled receptor...
Cyclic AMP receptor protein (CRP), also known as catabolite gene activator protein (CAP), is an important transcriptional regulator widely distributed in many bacteria. The biological processes under the regulation of CRP are highly diverse among differe
The protein levels of Ptch1 and Gli2 were further confirmed by western blot. Decreased levels of Ptch1 and Gli2 on day 3 were induced by T0 treatment (Ptch1: p < 0.01; Gli2: p < 0.01), but there was no obvious difference on day 1 (Ptch1: p > 0.05; ...
Innate-like B cells confined to the marginal zone of the spleen, the inner wall of the subcapsular sinus of lymph nodes, the epithelium of tonsillar crypts and the subepithelial area of mucosa-associated lymphoid tissues that can recognize conserved microbial antigens. Humoral immunity Describes par...