Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range of phenotypes. This review aims to give an account of recent work on the molecular basis of the properties of P2X receptors. In particular, to consider ...
The biophysical properties of large conducting (BK) potassium channels were unchanged, as were the pharmacological responses of the endogenous muscarinic and exogenous P2Y11receptors, both of which are cell surface receptors of the 7TM superfamily. Proteomic analyses revealed that although three proteins...
In addition, the properties and activation of these receptors can be altered by a large number of endogenous and exogenous modulators and non-competitive antagonists. Studies in our laboratory have focused on the modulation of NMDA receptors by polyamines such as spermine, which are present in high...
To date, little is known about the ligand specificities of individual Tlrs in fish, since the LRR ectodomains of Tlrs are not always highly conserved and sequence information alone cannot infer functional properties [10]. In apparent contrast to the variation in the ectodomains, intracellular TIR...
et al. Unexpected Properties of delta-Containing GABAA Receptors in Response to Ligands Interacting with the alpha + beta- Site. Neurochem Res 39, 1057–1067 (2014). Article CAS PubMed Google Scholar Ramerstorfer, J. et al. The GABAA Receptor α + β− Interface: A Novel ...
The epithelial cells of the gastrointestinal (GI) tract communicate with each other and with cells of other organs via a complex network of highly regulated movement of ions and biomolecules. The molecules ensure regulated activity of cells, tissues, and
(SPT). A single-molecule technique in which the motion of individual molecules is tracked with high temporal resolution over relatively long timescales (seconds); these tracks can be used to determine the diffusion properties of a molecule. Confined diffusion A mode of diffusion in which the motio...
Neutron diffraction study of the influence of structural disorder on the magnetic properties of Sr2FeMO6 (M=Ta, Sb) The crystal structure of the perovskite Sr 2FeTaO 6has been refined by simultaneous analysis of X-ray and neutron powderdiffraction data collected at 280... EJ Cussen,JF Vente,...
Their efficiency as anti-pruritic agents in urticaria and inclusion in the therapy of anaphylaxis are undisputed. The effects of H1R blockade in anaphylaxis critically depend on its vasoconstrictive properties. The anti-pruritic effects are mediated by a reduction of histamine-dependent release of ...
Despite the physiological importance and research advances in cell biology aspects of PGAP1, the biochemical properties and structural mechanisms of this unique lipase are not well understood. In fact, among the entire GPI-AP biogenesis pathway, only one enzyme has been recently structurally characteriz...