Here, we crossed astrocyte﹕pecific reporter mice hGFAP〤reERT2;Rosa‐tdTomato with APP/PS1 mice, and then used genetic tracing to characterize the morphological profiles and expression of molecular biomarkers associated with progressive β゛myloid deposits in the cortical region of AD mice. ...
Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K+buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoing morpho...
the striatum of an intact mouse.Middle, an image of an astrocyte in the ipsilateral striatum at 3 days after MCAO.Arrowheadsindicate phagocytic inclusions.Right, high-magnification image of the box shown in themiddle panel.Arrowindicates myelin-like structure. N, nucleus; M, mitochondria; in, ph...
Amyloid is one of the best characterized factors for triggering astrocyte reactivity. Delivery of pathogenic Aβ peptides to primary astrocytes (Pike et al., 1994), or intracranial delivery to intact animals (Craft et al., 2004) is associated with robust changes in astrocyte morphology. And, of...
Astrocyte variations and reactivity As opposed to being monolithic in function and morphology, astrocytes differ significantly depending on both tissue and cellular localization. Fibrous astrocytes have long fiber-like processes that associate with nodes of Ranvier along the axons that comprise the white ...
The astrocyte dataset encompassing 15,683 nuclei and 26,423 genes were filtered for genes expressed in less than 30 nuclei (< 0.2% of dataset) and nuclei expressing fewer than 2500 genes to respectively eliminate lowly expressed genes that increase statistical noise and data that may be derived...
Finally, we measured the size of the astrocyte soma found in the dentate gyrus; in agreement with the previous results, after 8 weeks of treatment, reactive astrocytes present an increase in the size of the cellular soma in response to Aβ-AChE complexes (Figure 8H), confirming the presence...
Astrocyte undergoes morphology changes that are closely associated with the signaling communications at synapses. N-myc downstream-regulated gene 2 (NDRG2)... Z Zhang,Z Ma,W Zou,... - J Cell Physiol 被引量: 0发表: 2019年 Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP...
These factors did not produce an A1-astrocyte phenotype alone or in combination. n = 8 per experiment. *P < 0.05, one-way ANOVA (increase compared to non-reactive astrocytes). Extended Data Figure 3 Screen for A1 mediators. a, Fold change data from published microarray datasets of...
(A′) Numerous IDO+cells showing astrocyte morphology (arrows) within an acute lesion (group 2). (A′′) Inflammatory lesion (group 4) with even higher density of IDO+cells with astrocyte morphology (arrows).(B)Control tissue with SRGN+astrocytes. (B′) Acute (group 2) and (B′′) ...