Tertiary amines may be prepared by reacting an aldehyde, hydrogen and a nitrogen-containing compound such as ammonia, a primary amine or a secondary amine in the presence of a rhodium- or ruthenium-containing catalyst at temperatures in the range of from about 50° to about 350° C. and a...
(Scheme 31).46This transformation involved the application of 1,3-acetonedicarboxylic acid as a reactive acetone surrogate performing a cascade di-decarboxylative Michael/aldol/dehydration sequence. First attempts implied the activation of the unsaturated aldehyde with a secondary amine chiral organo...
If the N,N′-disubstituted amidine is the desired product excellent yields can be obtained using four equivalents of the primary amine in ethanol or preferably DMSO as solvent. Amidines are formed from aliphatic nitriles by reaction with alkali amide bases (Equation (13)). Thus propane-, ...
A workflow for accelerated asymmetric reaction screening is established and verified by mapping the large-scale chemical space of more than 1600 reactions of α-asymmetric alkylation of aldehyde with organocatalysis and photocatalysis. Importantly, a class of high-enantioselectivity primary amine organo...
Although the Ugi multicomponent reaction is more than 40 years old, there is still room for its application to the discovery of new multicomponent transformations, even within the constraints of its classic four-reactant menu (aldehyde, amine, carboxylic acid, and isocyanide). Replacement of a pr...
The invention concerns a method of reducing the organoleptic effect of undesirable aldehydic components in a triglyceride or derivative thereof by addition of a reaction product of an amine and an organoleptically acceptable aldehyde. The triglyceride may be a food or food component such as an edible...
(1.57 g). The aldehyde group can be further functionalized to create complex molecules with just a few steps. For this purpose, we used multicomponent reactions (MCR) for further derivatization of the thiophene carbaldehyde7,10,19. Compound15ais of interest to test further reactivity due to...
stoichiometric equivalent ofbenzamide. Once formed, the Ae-alkoxide was thought to react with a second aldehyde via insertion into theAeO bond, thus generating a metallatedacetal derivative. This intermediate further reacted with an additional molecule of aldehyde in six-center concerted step to ...
22. Diastereofacial selectivity in the Lewis acid mediated reactions of allylsilanes with chiral aldehydes and enones The Lewis acid mediated reactions of chiral aldehydes 1-4 and enones 5-8 with allylsilanes 9 and 10 have been investigated. With aldehyde 1 and enones 5-7,... CH Heathcock,S...
The asymmetric addition of axially chiral amide to aldehyde 24 to generate the desired anti,anti-product 26 then proceeded with high selectivity (dr > 20:1). The absolute configuration of the product was confirmed by X-ray crystallography of a derivative. The asymmetric induction may be ...