Theoretical studies on enantioselective reduction of ketone with borane catalyzed by a B-methoxy-oxazaborolidine catalyst derived from pinene have been performed by means of the density functional theory (DFT) method. All the structures were optimized completely using wB97XD/6-31G(d,p) level and ...
them exceedingly valuable tools for organic synthesis. As an example, organomagnesium halides will undergo addition to the carbonyl bond of a ketone or aldehyde forming an adduct which is then hydrolyzed to form an alcohol. Hundreds of different alcohols have been synthesized via the Gri...
Reduction of the ketone followed by heating at 115 °C for 3 days gave 72 in 70% yield. Exposure of 72 to the action of SnCl4 effected a rearrangement to intermediate ketal 73 that was hydrolyzed to give 74 in 90% yield. Sign in to download full-size image Scheme 15. An ...
Friedel Crafts Acylation have several advantages over Friedel Craft Alkylation. These advantages include a better control over the reaction products and also the acylium cation is stabilized by resonance so no chances of rearrangement. Using Clemmensen reduction, the ketones made can be reduced to alky...
: the reduction of an aldehyde or ketone to the corresponding alcohol by reaction with boiling isopropyl alcohol in the presence of aluminum isopropoxide compare oppenauer oxidation Word History Etymology after Hans Meerwein and Wolfgang Ponndorf, 20th century German chemists ...
Reductive coupling of two ketone or aldehydes to form an alkene using low-valent titanium. ReactionMechanism View examples on Reaxys Chapters and Articles You might find these chapters and articles relevant to this topic. Syntheses of Photochromic Dihetarylethenes Mikhail M. Krayushkin, Marina A...
At the University of California, Berkeley, chemists have produced an antibody that selectively catalyzes the reduction of one of two nearly equivalent carbonyl moieties in a diketone [ Science , 260 , 337 (1993)]. In addition to exhibiting high regioselectivity in reducing the diketone, the ...
Mechanistic study of beta-substituent effects on the mechanism of ketone reduction by SmI(2) The ability of various functional groups to promote a chelated reaction pathway plays a crucial role in determining the rate of the reaction. Among the 2... E Prasad,RA Flowers - 《Journal of the Am...
MODULE 6 ORGANIC CHEMISTRY: REACTION MECHANISMS O3.1 O3.2 O3.3 O3.4 O3.5 O3.6 O3.7 O3.8 O3.9 O3.10 O3.11 Acids and Bases Carbanion Attack at a Carbonyl Group The Mechanism of Reduction Reactions Nucleophilic Attack by Water Nucleophilic Attack by an Alcohol Addition/Elimination Reactions of ...
reported the organocatalytic multicomponent reaction involving a combination of the iminium-catalyzed 1,4-reduction of α,β-unsaturated aldehyde and the fluorination of the resultant aldehyde (Scheme 4).15 In this reaction, two different catalysts 9 (7.5 mol%) for 1,4-reduction and 3 (30 mol%...