Direct reductive amination of ketones: Structure and activity of S -selective imine reductases from Streptomyces. ChemCatChem 6, 2248-2252 (2014).Huber T, Schneider L, Prag A, Gerhardt S, Einsle O, Muller M. Direct reductive amination of ketones: structure and activity of S-selective imine ...
Herein, a microorganism named Brevibacterium epidermidis ECU1015 that catalyzes the(S)-selective reductive amination of ketones with ammonium has been successfully isolated from soil. Using B. epidermidis ECU1015 as the catalyst, the asymmetric reductive amination of a set of phenylacetone derivatives ...
Direct reductive amination of ketones by reductive aminases (RedAms) is a promising method for the synthesis of primary, secondary and tertiary amines. In this work, five naturally occurring RedAms possessing reductive amination activity were identified using a structure-guided genome mining (SGGM)...
Brunel, Efficient diastereoselective Titanium(IV) reductive amination of ketones. Letters in Organic Chemistry, 2006. 3(5): p. 384-389.Salmi C, Letourneux Y, Brunel JM. Efficient diastereoselective titanium(IV) reductive amination of ketones. Lett Org Chem 2006;3:384 - 389....
Direct reductive amination of ketones by reductive aminases (RedAms) is a promising method for the synthesis of primary, secondary and tertiary amines. In this work, five naturally occurring RedAms possessing reductive ami
The asymmetric reductive amination of ketones enables the one-step synthesis of chiral amines from readily available starting materials. Here we report the discovery of a family of native NAD(P)H-dependent amine dehydrogenases (nat-AmDHs) competent for the asymmetric reductive amination of aliphatic ...
ChemInform Abstract: Regio‐ and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrroliz... ChemInform Abstract: Regio‐ and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrro...
Reductive Amination of Aldehydes and Ketones with Xylylene Ionene Bound Borohydride as a Novel Polymer Supported Reducing Agentamination, N‐alkylation, N‐arylationAn efficient reductive amination of aldehydes and ketones in the preparation of aliphatic and aromatic secondary and tertiary amines with ...
However, as most natural "reductive aminase" activities operate on keto acids, and many are able to use only ammonia as the amine donor, there is considerable scope for the engineering of natural enzymes for the reductive amination of ketones, and also for the preparation of secondary amines ...
The performance of Eco-Mn® was illustrated by the reductive amination of ketones, under solvent-free conditions, with the easily prepared and safe Hantzsch ester (HEH) as the reducing agent. A beneficial influence of water was observed with a model MnCl2-catalyzed reaction. Investigation of...