reductive aminationBiocatalysis employing imine reductases is a promising approach for the one-step generation of chiral amines from ketones. The enzymes reported for this process suffer from low activity and moderate stereoselectivity. We identified a set of enzymes that facilitate this reaction with ...
Herein, a microorganism named Brevibacterium epidermidis ECU1015 that catalyzes the(S)-selective reductive amination of ketones with ammonium has been successfully isolated from soil. Using B. epidermidis ECU1015 as the catalyst, the asymmetric reductive amination of a set of phenylacetone derivatives ...
Direct reductive amination of ketones by reductive aminases (RedAms) is a promising method for the synthesis of primary, secondary and tertiary amines. In this work, five naturally occurring RedAms possessing reductive amination activity were identified using a structure-guided genome mining (SGGM)...
The asymmetric reductive amination of ketones enables the one-step synthesis of chiral amines from readily available starting materials. Here we report the discovery of a family of native NAD(P)H-dependent amine dehydrogenases (nat-AmDHs) competent for the asymmetric reductive amination of aliphatic ...
8.02.3.2.3.1 Stepwise (indirect) reductive amination of aldehydes and ketones with amines Reductive amination of aldehydes with primary amines is the easiest reductive amination procedure. However, there were some cases where the formation of significant amounts of dialkylation was observed. Typically,...
However, as most natural "reductive aminase" activities operate on keto acids, and many are able to use only ammonia as the amine donor, there is considerable scope for the engineering of natural enzymes for the reductive amination of ketones, and also for the preparation of secondary amines ...
Magid et. al, Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride, Tetrahedron Letters., 1990, 31:5595.Abdel-Magid, A. F.; Maryanoff, C. A.; Carson, K. G. "Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride." Tetrahedron Lett. ...
Biocatalytic Imine Reduction and Reductive Amination of Ketones Chiral amines represent a prominent functional group in pharmaceuticals and agrochemicals and are hence attractive targets for asymmetric synthesis. Since ... JH Schrittwieser,S Velikogne,W Kroutil - 《Advanced Synthesis & Catalysis》 被引量...
Biocatalytic imine reduction and reductive amination of ketones. Adv. Synth. Catal. 357, 1665–1685 (2015). Google Scholar Hyslop, J. F. et al. Biocatalytic synthesis of chiral N-functionalized amino acids. Angew. Chem. Int. Ed. 57, 13821–13824 (2018). Article CAS Google Scholar ...
ChemInform Abstract: Reductive Amination of Aldehydes and Ketones with Xylylene Ionene Bound Borohydride as a Novel Polymer Supported Reducing Agentamination, N-alkylation, N-arylationChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 ...