REACTION PRODUCT OF KETONE AND AMINELUDWIG MEUSERPERCY JOSHUA LEAPER
aldehyde,amine,cyclization,imine,Mannich February 24, 2011 Leave a comment CBS Reduction Reactions alcohol,ketone,oxazaborolidine,reduction,stereospecific February 24, 2011 Leave a comment Vilsmeier-Haack reaction Vielsmeier-Haack reaction, is the reaction between a disubstituted formamide and phosphorus oxych...
In conclusion, the HWE olefination between bisphosphonates and aldehydes has proven its efficiency to conveniently prepare α-AVPs with various nitrogen moieties, such as formaldehyde, imine or amine. It is noteworthy that to date no report has been made to extend this methodology to the prep...
The enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand ( 1 ) was studied. Michael adducts ( 4 ) of up to 94% ee were obtained by the reaction between methyl ketones ( 2 ) and Michael acceptors ( 3 ) having a benzylidene group.doi:10.1002/chin....
The Suzuki reaction between 80 and 3-fluoro-4-iodopyridine (81) leads to the desired biaryl product 82 contaminated with primary amine (ca. 30%). Indole formation to β-carboline 83 was accomplished by boiling the mixture with pyridinium chloride at 215 °C. Subsequent N-methylation by using...
A highly enantioselective Mannich reaction between 3-substituted-2H-1,4-benzoxazines and acetone catalyzed by lipase from wheat germ type I (WGL) is described. Enantioselectivity of up to 95% ee was achieved in DMSO at 25 °C. This research provides a new and simple method for the synthesis...
Here is an example of a Michael reaction between the enolate of a malonic ester and an alpha, beta-unsaturated ketone (aka “enone”) where a strong base (NaOCH3 in this case) is used to form the enolate: (The pKa of malonic esters is usually around 13, so this is quite a favorable...
The boron-mediated ketone-ketone aldol reaction The first examples of the directed, boron-mediated aldol reaction between different ketones are presented. Transformation of a variety of ketones to their ... KM Cergol,P Turner,MJ Coster - 《Cheminform》...
It should be noted that this aminative multifunctionalization of internal alkynes directly lead to the skeleton of a-tertiary amine derivatives, which are widespread in various natural products and bioactive compounds52–55. Quaternary carbon centres with a nitrogen substituent have been successfully ...
the rearrangement product becomes the nucleophilic part. Jung has applied this method in the synthesis of 1,5-bis-silyloxy-3-alkanone by introduction of a hindered amine base and silyl triflates, which will give a silyl enol ether intermediate for the following aldol reaction (Scheme 125).142...