参考文献 [1]Mast cells:an expanding pathophysiological role from allergy to other disorders[J].Preet Anand,Baldev Singh,Amteshwar Jaggi,Nirmal Singh.Naunyn-Schmiedeberg’s Archives of Pharmacology.2012(7) [2]Zaditen(Ketotifen),as mast cell blocker,improves sperm quality,chromatin integrity and pregnan...
Passante E, Ehrhardt C, Sheridan H, Frankish N. RBL-2H3 cells are an imprecise model for mast cell mediator release. Inflamm Res 2009; 58: 611-8.Passante E, Ehrhardt C, Sheridan H, Frankish N (2009) RBL- 2H3 cells are an imprecise model for mast cell mediator release. Inflamm Res ...
摘要:肥大细胞在过敏性疾病发生中起关键作用,而RBL-2H3细胞系作为大鼠嗜碱性粒细胞系(rat basophilic leukemia,RBL)的一个亚系,可以表达肥大细胞的许多特性和功能,因此常作为过敏性疾病研究的替代模型。RBL-2H3细胞系常用作过敏反应中肥大细胞脱颗粒和激活机制方面的...
tablishedapharmicmodelonthedegranulationofRBL-2H3mastcells,activatedbycompound48/80(10mL).PretreatedRBL-2H3cellswithdiferentdilutionsofpaeonol,Thehistamineandtumornecrosisfactor—alpha(TNF—)fromthesupernatants,thespontaneouslyreleasedhistamineandthetotalhistaminewerealldeterminedbyELISA.ResultsPaeonolofdiferentconcen...
类过敏反应;中药注射剂;肥大细胞脱颗粒;RBL-2H3细胞;β-氨基己糖苷酶释放率R283.6A1005-9903(2011)22-0152-06StudiesonDegranuationofRatPeritonealMastCellsandRBL-2H3CellsCausedbyTraditionalChineseMedicineInjectionsLIYong-meiLIUJiongZHAOYuanTANGJia-ming2011-04-27科技部重大新药创制基金项目(2009ZX09502-002)...
Key words Tween 80; pseudoallergy; mast cells; β-hexosaminidase; MTT 中药注射剂的安全性问题越来越受关注,其不 良反应中出现较多,危害较大的是过敏反应,从轻 度的皮疹到致命的过敏性休克.在中药注射剂引起 的过敏性休克中,约 3/4 属于类过敏反应[1].中药 注射剂引发类过敏反应的重要原因之一是其注射用...
They have been used extensively to study FcERI and the biochemical pathways for secretion in mast cells. RBL-2H3 cells have been the model for studies of structure of FcERI. They have been used extensively for studies of different aspects of secretion in cells including the role of changes ...
摘要: Objective The cell line, RBL-2H3, has been widely used as a mast cell model though much of the data is contradictory. The aim of this study is to assess the RBL-2H3 cell line as an in vitro model for...关键词:RBL-2H3 Mast cell Toll-like receptors ...
Inhibitory activity of Chrysanthemi sibirici herbaextract on RBL-2H3 mast cells and compound 48/80-induced anaphylaxis [J]. J Ethnopharmacol, 2004, 95(2-3) 425-430. [18] Coor E A, Seybold H, Merk H F, et al. Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions ...
RBL-2H3细胞These cells have high affinity IgE receptors. They can be activated to secrete histamine and other mediators by aggregation of these receptors or with calcium ionophores. They have been used extensively to study FcERI and the biochemical pathways for secretion in mast cells. ...