Cancer immunotherapy Agonist 1. Introduction The goal of anticancer immunotherapy is to re-establish and enhance the antitumour immune response without causing concomitant autoimmunity that may itself result in significant morbidity. In some cases, it is sufficient to block immunomodulatory molecules respons...
benefit from immunotherapy [9,10,11]. The rationale for cancer immunotherapy can be summarized as reversing the tumors immuno-suppressive effects of the tumors or enhancing the inherent anti-tumor immune responses of the host [12]. The main cancer immunotherapy approaches include ICIs, cancer vaccin...
benefit from immunotherapy [9,10,11]. The rationale for cancer immunotherapy can be summarized as reversing the tumors immuno-suppressive effects of the tumors or enhancing the inherent anti-tumor immune responses of the host [12]. The main cancer immunotherapy approaches include ICIs, cancer vaccin...
Cancer immunotherapy has become an important area for the future development of cancer therapy; this includes T-cell-based therapies that involve adoptive transfer of autologous T cells derived from the tumors or peripheral blood of cancer patients, vaccines, oncolytic virus therapy, and immunomodulatory...
surgically resected human PDAC collected from a previous clinical trial treated with the neoadjuvant combination therapy of nivolumab (anti-PD-1 antibody), urelumab (anti-CD137 agonist antibody), and the pancreatic cancer GVAX vaccine.Methods:C57BL/6 mice were orthotopically implanted with KPC tumors...
rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature Anna Hagström1*, Ruba Kal Omar1*, Pete A. Williams2 and Gustav Stålhammar2,3 Abstract Background: Uveal melanoma is a rare form of cancer with high mortality....
[25,155,157]. Therefore, EMT means a transition from an almost unknown cellular state to an unknown cellular state. It is incomprehensible how an unknown cellular state can be used as standard reference for the properties of other cells or endows different cellular properties to cancer cells, ...
Importantly, these indirect effects of radiation – within and outside the field of treatment – also suggest new treatment possibilities, including combinations with estab- lished or novel forms of immunotherapy. Immune checkpoint blockade as novel immunotherapeutic strategy in cancer The introduction of...