radioimmunotherapies, such as iodine-131 anti-CD138 monoclonal antibody (mAb), have suggested that CD138-directed cytotoxicity therapy may be a clinically effective approach and is at least an alternative therapeutic strategy, especially for those patients refractory to chemotherapy and with progressive ...
CD138 x SLAMF7 x XBP1 A Single-Arm, Open-Label, Multi-Center Phase II Study to Evaluate the Combination of PVX-410 + Pembrolizumab + Chemotherapy for Frontline Therapy of Metastatic, PD-L1+ Triple-Negative Breast Cancer (TNBC) in HLA-A2-Positive Patients Evaluating the combination of the in...
WithEasySep™, the desired cells are targeted using antibody complexes recognizing CD138 on the surface of the cell and linking the cells to magnetic particles. The sample is then placed in an EasySep™ magnet, the labeled cell...
However, the infiltration of CD138 plasma cells in solid tumors has been associated with longer survival in patients with ovarian, gastroesophageal, NSCLC, and colon cancers27. These effects might be augmented by the localization within tumor, which would enable high concentrations of antibody to ...
Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM). We found that the CD19−CD38hiCD138...
(c) HPSElow and HPSEhigh cells are plated on VCAM-1 in the absence or presence of 10 μg/ml MMP-9 inhibitory antibody (bar = 50 μm). (d) HPSElow and HPSEhigh cells were grown at equal densities in serum-free media for 48 h in the absence or presence of MMP-9 blocking ...
At later disease stages, intrathecal antibody production and main- tenance of the disease process despite systemic immuno- therapies (with a weak impact on the CNS compartments) has been postulated to be due to the infiltration of B cells and plasma cells into the CNS parenchyma as well as ...
Thus, we consider the activation of cytotoxic CD8+ T cells within the CSF (and putatively CNS) stronger than that of CD19+ B cells. The patient received intravenous methylprednisolon pulse-therapy together with plasma-exchange, which had no significant clinical effect. Three months later an ...
16. An anti-CD138 antibody molecule comprising one or both of: (a) a heavy chain variable region (VH), wherein the VH comprises three heavy chain complementarity determining regions (HCDR1, HCDR2, and HCDR3), wherein the VH comprises one, two, or all of the following: (i) an HC...
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