This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It acti...
protein-coding gene 同源简称(alias symbol) CalDAG-GEFII|RASGRP 基因家族代码(gene_family_id) 863[HGNC][GenScript] omim代码 603962 entrez码 10125[Vega] ensembl基因码 ENSG00000172575[Ensembl] 基因家族(gene family) EF-hand domain containing
RUNX1RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1ヾeficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity....
Ensembl Gene IDENSG00000172575.14 Ensembl mRNA IDRASGRP1-201 包装清单: 产品编号产品名称包装 QH07449SHuman RASGRP1 qPCR Primer Pair1nmol each —说明书1份 保存条件: -20℃保存。建议复溶后进行适当分装,避免反复冻融。 注意事项: PCR扩增产物的长度可能会因基因转录后存在多种剪接形式而有所差异。
In T cells, TNFα increased RasGRP1 gene expression level but RasGRP1 protein expression level decreased, inhibiting T cell proliferation and TCR pathway phosphorylations. Conclusions This study suggests a link, never described previously, between RasGRP1 or RasGRP3 and the TNFa effects on T and B...
(ChIP-Seq) on LPS-induced inflammation in BV2 cells and finally identified theRasGRP1gene as a novel target of Nurr1. Here, we show that Nurr1 directly binds to theRasGRP1intron to regulate its expression. Moreover, we also identified that RasGRP1 regulates the Ras-Raf-MEK-ERK signaling ...
Figure 3. RNA-seq analysis identifies ETP-related gene signatures enriched in Kras−/−; NrasQ61R/+ thymocytes. RNA-seq analysis of thymocytes from moribund Kras−/−; NrasQ61R/+ (K−/−; Q/+) mice (n = 3) and age-matched controls (con) (n = 3). (A) Volcano plot ...
Genome-wide association studies have validated the RAS guanyl nucleotide-releasing protein 1 (RASGRP1) gene as a type 2 diabetes (T2D) susceptibility locus.This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population....
Therefore, we cloned a gene for the enzyme from YRC001. The nucleotide sequence of a 2,940-bp XbaI fragment containing the gene was analyzed. The gene encoded 849 amino acids, and the calculated molecular mass for the mature enzyme (initial methionine is removed) was ...