The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of ...
The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of ...
2012. Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. Eur J Med Genet 55:191-195.de Wijn RS,Oduber CE,Breugem CC,et al.Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. Eur J ...
The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of ...
背景资料RASA1,also known as RAS p21 protein activator 1,is a 120-kDacytosolic human protein.The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins.The gene product stimulates the GTPase activity of normal RAS p21 but not it...
保存条件-20℃可保存1年,短期保存或频繁使用请置于4℃,可保存一个月,避免反复冻融。 背景资料RASA1,also known as RAS p21 protein activator 1,is a 120-kDacytosolic human protein.The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating pr...
(tumour–node–metastasis (TNM)) T1 1 T2 4 T3 12 T4 7 4.2 16.7 50.0 29.1 Histology type Well differentiated Moderately differentiated Poorly differentiated 4 15 5 16.7 62.5 20.8 and codon 13, two hot spots that include 495% of mutations in this gene, were detected as previously reported ...
22, 23 Clones that demonstrated a twofold reduction in the intron 18 target were analyzed further by quantitative real-time PCR using a copy number primer/probe set based within exon 14 of the Rasa1 gene (Life Technologies, Carlsbad, CA). Of those clones that contained diploid amounts of ...
Therefore, we hypothesized that RASA1, an important member of the RAS-GAP family, which is significantly down-regulated in colon cancer, may negatively regulate the RAS signaling pathways and act as a tumor suppressor gene. Indeed, we found that RASA1 up-regulation inhibited cell proliferation an...
Furthermore, a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21. Then, changes in mRNA and protein levels of RASA1, RAS-GTP, and other components of the RAS signaling pathways were assessed in transfected RKO cells by real-time quantitative reverse ...