该系统怎样进行信号传导?答:胰岛素所激发的信号转导传递途径主要有,一为Ras-MAP激酶途径,一为PI-3-激酶途径。(一)Ras-MAP激酶途径:胰岛素与胰岛素受体集合后,引起受体自身磷酸化,从而使其酪氨酸蛋白激酶活化,后者立即使胞质内IRS-1及She的酪氨酸磷酸化,形成的磷酸酪氨酸残基为含SH2 和Grb2结合。Grb2由2个SH3...
Ras是一种GTPase switch蛋白,位于大多数RTK和细胞因子受体的下游 单体Ras蛋白是一种“开关”蛋白,它在与GTP结合的活性“开关”状态和与GDP结合的非活性“开关”状态之间交替。与三聚体G蛋白不同,Ras并不直接与细胞表面受体相连。而与三聚体G蛋白一样的是,Ras的活性也受到其他几种蛋白质的调节。鸟嘌呤核苷酸交换因子...
Shapiro P (2002) Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy. Crit Rev Clin Lab Sci 39:285-330Shapiro, P. (2002). "Ras‐MAP kinase signaling pathways and control of cell proliferation: relevance to cancer ...
在线MAP转RAS,不用下载任何软件,就可将电脑,平板或手机中的MAP转RAS格式! 步骤1 上传MAP文件 从计算机,Google Drive,Dropbox,URL或在页面上拖拽选择文件. 步骤2 选择'转RAS' 选择输出RAS或任何其他格式作为转换结果(点击转换按钮) 步骤3 下载你的MAP文件 ...
Regula- tion of p53 expression by the RAS-MAP kinase pathway. Oncogene 2001;20:2527-36.Agarwal MK, Wolfman A, Stark GR. Regulation of p53 expression by the RAS-MAP kinase pathway. Oncogene 2001; 20:2527–2536.Agarwal, M. L., Ramana, C. V., Hamilton, M., Taylor, W. R., De...
Fundo Lumbreras is a locality in Mala District, Cañete Province, Lima region. Mapcarta, the open map.
Kryakouras is a peak in Greece and has an elevation of 2,118 metres. Mapcarta, the open map.
Tan PB, Kim SK (1999) Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 15:145–149Tan, P.B., Kim, S.K.: Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet. 15 (... PBO Tan,SK Kim 被引量: 172发表: 1999年 Selective re...
百度试题 题目生长因子调控细胞存活的信号通路是( )A.cAMP-PKAB.PLC-IP3C.RTK-Ras-MAPKD.RTK-PI3K-PKB 相关知识点: 试题来源: 解析 D 反馈 收藏
Online, interactive map of Ras Al Khaimah (RAK) city and emirate from OpenStreetMaps data. Scroll with mouse for zoom in or out. Click and drag to view other areas and emirates in the UAE.