(2009) Ras-MAPK pathway as a therapeutic target in cancer--emphasis on bladder cancer. Recent Pat Anticancer Drug Discov, 4, 125-36.Dangle PP, Zaharieva B, Jia H, Pohar KS. Ras-MAPK pathway as a therapeutic target in cancer-- emphasis on bladder cancer. Recent Pat Anticancer Drug ...
引用: Eleveld TF, Oldridge DA, Bernard V, et al. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet. 2015;47(8):864–871. doi:10.1038/ng.3333 END
The Ras-MAPK (mitogen-activated protein kinase) signal transduction pathway is well known to control cellular proliferation and differentiation in response to extracellular signals, but its other functions are less understood. InCaenorhabditis elegansthis pathway regulates several developmental events, such a...
3) MAPK pathway MAPK途径 1. The phosporylation of ERK1/2,an indicator of the activation of MAPK pathway was also determined by West. 为研究雌激素促进前列腺间质细胞增殖的机理,使用雌二醇(E2)或BSA雌二醇(BSA-E2)处理前列腺间质细胞系wpmy-1,用MTT法及细胞计数法检测细胞增殖情况;用实时RT-PCR...
Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting.Front Oncol.2014;4:160. 10.Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, Kasahara A, Ueki T, Hirano T, Yamamoto H, Fujimoto J, et al. Activation of mitogen-activated protein ...
Ras以及Raf活化本身是Ras signaling pathway(ko04014)核心步骤。如果关心这个过程中的相关调控,可以单独查询这个通路。 (b)MEK(MAPKK)与ERK(MAPK)的活化 活化的Raf激酶会磷酸化MEK的218位和222位的丝氨酸。活化的MEK会磷酸化ERK1/ERK2的183位的苏氨酸和185位的酪氨酸,形成双磷酸化完成活化。
Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations[J]. Genet Med, 2012,14(3):285-292. doi: 10.1038/gim.0b013e31822dd91f . 返回引文位置Google Scholar 百度学术 万方数据 [5] White SM , Graham JM Jr, Kerr B ,et ...
Synonyms Male Turner ; Ras/Mapk pathway syndromes Short Description or Definition Noonan syndrome (NS) is a multiple malformation genetic disorder characterized by dysmorphic facies including hypertelorism, ptosis, low-set posteriorly rotated ears, short neck, and relative macrocephaly. Associated ...
Accessory proteins of the RTK-RAS-MAPK pathway New discoveries and concepts regarding the receptor-driven RAS-MAPK signal transduction have emerged during the last three decades: novel pathway components, structure elucidation, biophysical principles, biomimetic strategies and clinical drug candidates. By ...
Classification as a NSGCT rather than a SGCT was associated with an increased risk of death (HR 9.1, 95% CI 1.1-78.4, p = 0.04) while the presence of a concurrent RAS/MAPK pathway alteration was not (HR 0.8, 95% CI 0.1-4.3, p = 0.76). Conclusions Mitogenic driver alterations can ...