A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large B-cell lymphoma (DLBCL) specimens. ...
Product NameRas-interacting protein 1 CAS CBNumberCB02895105 MW0 MOL FileMol file Chemical Properties storage temp.-20°C formbuffered aqueous solution biological sourcerabbit UNSPSC Code12352203 NACRESNA.41 Ras-interacting protein 1 Price Preparation Products And Raw materials ...
Autism-related mutations within the SHANK3 SPN domain (R12C and L68P) disrupt G-protein interaction and fail to counteract integrin activation along the Rap1–RIAM–talin axis in cancer cells and neurons. Altogether, we establish SHANKs as critical regulators of G-protein signalling and integrin...
Its activity is enhanced by the numb-binding protein in vivo and controls filopodia formation (8). GAP proteins have also been involved in dendritic spine morphogenesis during development. For instance, the Rho-GAP protein oligophrenin-1 has been shown to regulate the length of dendritic spines ...
1 However, PNETs often display an indolent phenotype, resulting in late diagnosis at advanced stages when surgical resection with curative intent is no longer an alternative.2,3 Sunitinib (a multitargeted protein tyrosine kinase inhibitor), everolimus (a mammalian target of rapamycin inhibitor), ...
A novel protein which interacts with ras p21, has been identified. This protein, RGL, shares 69% amino acid homology with ral guanine nucleotide dissociation stimulator (ralGDS). ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through ...
ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through the effector loop of ras p21. Polypeptide and polynucleotide compositions of the RGL protein are provided as well as methods for implementing the diagnostic and therapeutic uses of ...
ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through the effector loop of ras p21. Polypeptide and polynucleotide compositions of the RGL protein are provided as well as methods for implementing the diagnostic and therapeutic uses of ...
A cytoplasmic protein of MW 110–120,000 has recently been identified by its capacity to enhance 100–500 fold the GTPase activity of ras-p21s (GAP) 2 ; it has been shown to interact with a domain of p21s necessary for their biological activity (amino acids 30–42 called "effector ...
Ras-related protein Rab-7aglucose metabolismhypoxia-inducible factor 1-alphahypoxiaHepG2Ras-related protein Rab-7a (RAB7A) is a member of the RAS oncogene superfamily; it plays an important role in vesicle transport. In this study, we described the mechanism of RAB7A-dependent regulation of ...