Ras GTPase Inhibitors Cat. No.产品名称/活性 7713AMG 510 Potent and selective KRASG12Cinhibitor 6791BC-LI-0186 Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor 6407Fendiline Hydrochloride Inhibits KRas localization to the plasma membrane; also L-type ...
中文名称:RAS GTPase 抑制剂1英文名称:RAS GTPase inhibitor 1 CAS:2252242-32-1品牌:TargetMol 产地:美国保存条件:Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. 纯度规格:99.66%产品类别:抑制剂
RAS GTPase 抑制剂1 T12692服务地域:全国 产品属性:品牌:TargetMol;产地:美国; 产品参数: 货号:;规格...发布时间:2024年06月 产品描述 Product IntroductionBioactivity英文名: RAS GTPase inhibitor 1描述: RAS GTPase inhibitor 1 是一种 RAS GTPase 抑制剂,具有潜在的抗肿瘤活性。
RAS GTPase inhibitor 1 中文别名: 化合物 T12692;RAS GTPASE 抑制剂1 CBNumber: CB68054515 分子式: C27H28ClF4N5O2 分子量: 566 MOL File: 2252242-32-1.mol 化学性质安全信息用途供应商5 RAS GTPase inhibitor 1化学性质 安全信息 RAS GTPase inhibitor 1性质、用途与生产工艺 ...
大家好,今天给大家分享一篇来自JMC的文章“Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor”,发表于2021年8月,作者来自是美国俄亥俄州立大学综合癌症中心的裴德华教授,毕业于武汉大学。 故事的开始,有必要讲一下Ras靶点。RAS是肿瘤患者中最常见的致癌基因之一,...
Importantly, in vivo generation of collagen type-II specific effector CD4+T cells was likewise repressed by FTS therapy.#The RasGTPases inhibitor FTS attenuates the production of proinflammatory cytokines by in vitro-activated T cells and is a potent immunomodulatory compound in the CIA model, ...
[2] Matthew R Janes, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018, 172(3): 578-589. >>> 相关产品 K-Ras-IN-1 K-Ras-IN-1是一种Kras抑制剂。 Oncrasin-1 Oncrasin-1是高效的抗癌抑制剂,能低浓度下杀死各种Kras突变型人肺癌细胞。 ARS...
Function : Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. Subcellular Location : Cytoplasm. ...
(Effector protein)相互作用,从而刺激细胞发生相应的响应;GTP酶激活蛋白(GTPase-activating proteins, GAPs)催化小GTP酶结合的GTP水解为GDP,并释放自由磷酸盐(Free phosphate, Pi),此时小GTP酶结合GDP进入静息状态(Inactive state),鸟嘌呤核苷酸解离抑制蛋白(Guanine nucleotide dissociation inhibitors, GDIs)抑制小GTP酶...
K-Ras-InhibitorenLigandendesignNMR-SpektroskopieK-Ras is a small GTPase that functions as a molecular switch cycling between inactive (guanosine diphosphate [GDP]-bound) and active (guanosine triphosphate [GTP]-bound) states. The conversion of K-Ras-GDP to K-Ras-GTP is the rate-limiting ...