Ras GTPase is a prototype for nucleotide-binding proteins that function as molecular switches in a variety of cellular functions. The switch is modulated by cycling between the inactive GDP bound form and the active GTP bound form, regulated by the opposing actions of guanine nucleotide exchange ...
Function : Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amin...
促进性 GLUT1 和 GLUT3 六糖转运体在巨噬细胞中大量表达,但它们是否具有不同的功能仍不清楚。我们证实巨噬细胞在受到 M1 极化刺激后 GLUT1 表达增加,并发现巨噬细胞在受到 M2 刺激后 GLUT3 表达增加。条件性缺失 Glut3(LysM-Cre Glut3fl/fl)会影响骨髓来源巨噬细胞的 M2 极化。来自特应性皮炎患者皮肤的替...
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function CLEC6A Antibody (Clone#ABM2H28) Anti-CLEC6A Antibody (Clo...
别名GAP1 like protein; MRASAL; RAS GTPase activating protein like; RAS protein activator like 1 (GAP1 like); RAS protein activator like 1; RASAL; Rasal1; rasGAP activating like protein 1; RasGAP-activating-like protein 1; RASGAP1 LIKE; RASL1_HUMAN. ...
Difficulty in fully defining RAS-driven signaling stems from the overall complexity of downstream pathways and a lack of tools for specifically perturbing RAS function. To better characterize RAS-driven signaling, we recently developed a chemical genetic system for activating endogenous RAS with a ...
Abstract In addition to their role as oncogenes, Ras \{GTPases\} are key regulators of cell function. There is a proven relationship between the signaling pathways of transforming growth factor-β1 (TGF- β1) and Ras GTPases. Each of the Ras isoforms (H, N and K) exhibits specific ...
Here we show that when signalling through the Ras-related GTPase Rho is inhibited, constitutively active Ras induces the cyclin-dependent-kinase inhibitor p21and entry into the DNA-synthesis phase of the cell cycle is blocked. When Rho is active, induction of p21by Ras is suppressed and Ras ...
function,the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS,thereby allowing control of cellular proliferation and differentiation.Mutations leading to changes in the binding sites of either protein are associated with basal cell ...
论文--毕业论文 文档标签: RasRASlikeras 系统标签: rasgtpaselike �.BiochimicaetBiophysicaActa13331997M19–M31Mini-ReviewRas-likeGTPasesJohannesL.Bos)LaboratoryforPhysiologicalChemistry,UtrechtUni˝ersity,Uni˝ersiteitsweg100,3584CGUtrecht,TheNetherlandsReceived28April1997;accepted12May19971.IntroductionTh...