SummaryTwo clones, pCN1 and pCN2, which together form full-length cDNA for N-ras, were used to search for restriction fragment length polymorphisms. pCN2, which entirely consists of 3′ non-translated sequences, revealed more bands on DNA transfer hybridizations than could be accounted for usi...
In this report, we isolated and characterized a novel Ras small monomeric GTPase Rsr1 gene, designated PmRsr1 , from yeast-form Penicillium marneffei . The full-length PmRsr1 cDNA sequence is 1,866bp in size, and contains an open reading frame of 642bp encoding 213 amino acids. The ...
Nonetheless, the switch I and II regions, which form the major sites for the interaction of ARF proteins with their cellular partners61, suggest that Rasarfin may also bind in these regions. Moreover, despite the very conserved homology between ARF6- and ARF1-bound to GDP, the few sequence...
(RNAi). A method of gene silencing in which short, double-stranded RNA molecules degrade target mRNAs in a sequence-specific manner to inhibit the expression and function of genes of interest. GTPase An enzyme that binds and hydrolyzes GTP to GDP. GTP binding and hydrolysis take place within ...
which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome ...
Legius syndrome is a recently recognized, milder form of neurofibromatosis type 1, in which the NF1 gene is intact, but, instead, loss-of-function mutations occur in SPRED1, a previously known suppressor of RAS/MAPK signaling. SPRED stands for Sprouty-related EVH1-domain containing protein (Bre...
Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), have been utilised to explore these context effects. BPDE is known to form an adduct a
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Overall, our work strongly suggests that the selective increase in wild-type cell divisions during injury repair of mosaic skin limits the expansion of mutant cells expressing different oncogenic variants of the Ras gene family. Molecular mechanism upon injury ...
Full size image There was a more than twofold bias towards Ras-associating protein mutation in GCB (11/24; 46%) versus ABC (3/14; 21%). Further, the gene expression level ofRAS,RAF, and RAS-associating proteins at relapse were higher in GCB-DLBCL compared to ABC-DLBCL (Fig.2B–E, ...