James W. LarrickSpringer New YorkBurck KB,et al.ras family of oncogenes. Ibis . 1988Burck KB, Liu EJ, Larrick JW. ras family of oncogenes. In: Onco- genes: An Introduction to the Concept of Cancer Genes. New York Springer-Verlag, 1988; 192-197....
Ras and relatives—job sharing and networking keep an old family together One simple answer to the question of why there are so many similar members of theRas subfamilywould be that they would be activated by differentGEFsthat were themselves activated by different stimuli. Indeed there are many...
phenotypically normal skin contains a mosaic of epithelial stem cells with somatic mutations, including in genes that are associated with cancer development, such as the GTPase Ras family1,2. Constitutive activation of Ras oncogenes has been identified as ...
TheRASfamily of proto-oncogenes comprisesHRAS,KRAS, andNRAS, which are among the most mutated genes in human cancers. TheRASfamily genes encode small GTPases that coordinate key signaling pathways in response to growth factors. Mutations inRASresult in a constitutively active form of the protein ...
(derived from 'RAt Sarcoma' virus) gene family include KRAS, HRAS, and NRAS. These genes encode immunologically related proteins with a molecular mass of 21 kD and are homologs of rodent sarcoma virus genes that have transforming abilities. While these wildtype cellular proteins in humans play ...
These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies, and many psychiatric disorders, mutations in the RAS genes or their regulators render RAS proteins persistently active. The structural basis of the switch and many of the pathways that RAS ...
Ray P and Lakhotia S C (1996) Interaction of the non-protein- coding developmental and stress-inducible hsr gene with Ras genes of Drosophila melanogaster J Biosciences 23 377-386Ray P and Lakhotia S C (1996) Interaction of the non-protein- coding developmental and stress-inducible ...
Methylation in promoter regions of PITX2 and RASSF1A genes in association with clinicopathological features in breast cancer patients association (RalGDS/AF-6) domain family member 1 isoform a (RASSF1A) and a member of the paired-like homeodomain transcription factor family which ... E Jezkova...
We utilized a retrovirus-based cDNA expression system to identify transforming genes expressed in cytogenetically normal AML patients. We identified a new member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors, designating it RasGRP4. ...
RAS genes are the most commonly mutated oncogenes in cancer, but effective therapeutic strategies to target RAS-mutant cancers have proved elusive. A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, leading researchers to test numerous alternative...