Conversely, in normal cells RAP GTPases may also function to position AFDN-SCRIB at emerging sites of cell-cell adhesion to initiate and couple AJ formation to establishment of polarity. In addition to SCRIB there are several noteworthy hits in the AFDN BioID dataset, many of which are ...
RAS [169]. ZM336372 was the first small-molecule, ATP-competitive RAF inhibitor developed, targeting CRAF in cancer [170], However, among the first-generation RAF inhibitors, only Sorafenib progressed to clinical use and received FDA approval for treating advanced renal cell carcinoma...
Ras genes are pre-eminent genes that are frequently linked with cancer biology. The functional loss of ras protein caused by various point mutations within the gene, is established as a prognostic factor for the genesis of a constitutively active Ras-MAPK pathway leading to cancer. Ras signaling ...
Xu Q, Liu X, Liu Z, et al. MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway. Mol Cancer. 2017;16:103. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new...
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A. Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, ...
30. MacNicol MC, Muslin AJ, MacNicol AM. Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation. J Biol Chem. 2000;275(6):3803–9. 31. Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz ...
Available add-ons Advanced Security Enterprise-grade security features Copilot for business Enterprise-grade AI features Premium Support Enterprise-grade 24/7 support Pricing Search or jump to... Search code, repositories, users, issues, pull requests... Provide feedback We read every piece...
Clarke NE, Turner AJ. Angiotensin-converting enzyme 2: the first decade. Int J Hypertens. 2012;2012:307315. doi:10.1155/2012/307315 (Open in a new window)PubMed(Open in a new window)Google Scholar Chappel MC, Ferrario CM. ACE and ACE2: their role to balance the expression of angioten...
There is still no reliable therapeutic targets and effective pharmacotherapy for metabolic dysfunction-associated steatotic liver disease (MASLD). RASD1 is short for Ras-related dexamethasone-induced 1, a pivotal factor in various metabolism processes of
Abstract Purpose of Review The renin-angiotensin system (RAS) plays an important role in modulating cardiovascular function and fluid homeostasis. While the systemic actions of the RAS are widely accepted, the role of the RAS in the brain, its regulation of cardiovascular function, and sympathetic ...