将于t‑BuOH(70mL)中 的(E)‑3‑环丙基丙烯酸甲酯(3.5g,27.74mmol,1eq)添加至混合物中并在室温下搅拌15小 时。将混合物用饱和NaSO(100mL)淬灭,接着用EtOAc(3×200mL)萃取。将合并的有机层用 223 盐水(100mL)洗涤并经NaSO干燥,过滤并减压浓缩滤液,得到残余物。将残余物通过硅胶柱 24 色谱法(0→...
[0142]2213 在一些实施方案中,R为H。在一些实施方案中,R为未取代或用一个或多个R取 1322 代的C烷基。在一些所述实施方案中,每个R独立地选自‑OR(例如‑OH)和‑CN。在一些实 1‑6 222 施方案中,R选自C烷基。在一些实施方案中,R选自C烷基。在一些实施方案中,R选自‑ 1‑61‑2 2 CH、‑...
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RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. Mol. Cell Biol. 27, 8127–8142 (2007). Article CAS PubMed PubMed Central Google Scholar Zhang, S. et al. Rho family GTPases regulate p38 mitogen-activated protein kinase through ...
All statistical testing for data presented was performed using pairwise Student’s t test as indicated by brackets. We furthermore tested the requirement for the p190A-RasGAP interaction to elicit MET. Unlike p190A(WT), expression of p190A(Y2F) did not promote an N- to E-cadherin switch ...
This forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) man
calculated (E.g. 3): Tλhi reepprroesjeecnttiothnePirrcooj(rMre,spPoCni)dionfgaanmy pstlrituucdteusr.eT(hsenafiprssthfoetw) PCs describe collective M onto the ith PC was Proj[M, Vi] = Mα ⋅ Vi where Mα is the Cα atoms of proteins after overlaying M with the reference ...
Brain 2002, 125, 2213–2221. [Google Scholar] [CrossRef] [PubMed] [Green Version] Michailov, G.V.; Sereda, M.W.; Brinkmann, B.G.; Fischer, T.M.; Haug, B.; Birchmeier, C.; Role, L.; Lai, C.; Schwab, M.H.; Nave, K.-A. Axonal Neuregulin-1 Regulates Myelin Sheath ...
医院许可证号:PDY56493466349076T2213 9、普洱市思茅区人民医院(普洱市中心医院) 医院类别:公立三甲 医院许可证号:PDY71132513377164K3305 10、遂宁市中心医院整形美容科 医院类别:公立三甲 医院许可证号:PDY58004937162847L2573 11、佛山市第一人民医院 医院类别:公立三甲 ...