ras+2213tl+w

2025-03-28 09:25:22

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共价RAS抑制剂及其用途.pdf-原创力文档

(ensartinib)(X‑396);洛拉替尼(lorlatinib);ASP3026;CEP‑37440;4SC‑203;TL‑398; PLB1003;TSR‑011;CT‑707;TPX‑0005和AP26113。ALK激酶抑制剂的其它实例描述于 W实施例3‑39中。 [0245]在一些实施方案中,抗癌剂是受体酪氨酸激酶(RTK)/生长因子受体下游成员的抑制剂(例如SHP2、SOS1抑制...
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway...

Drummond MW, Holyoake TL . Tyrosine kinase inhibitors in the treatment of chronic myeloid leukaemia: so far so good. Blood Rev 2001; 15: 85–95 (Review). CAS PubMed Google Scholar Schulte TW, Neckers LM . The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 ...
...Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

For each onco- (gCFeonigmi.c p2maCru)e,tdaGnto1t,2tthVhee(pFplirogot.b o2afDbKi)l-,iRtayandsd4isBGtWr1iTb3-uDGtiT(oFPnisg(F.o 2ifgEd. 1)2amAn)ud,ttdahn2etwps,erraoenbcdaabtliocliutaylaldteesidssterfroibreuxtthtieoenndts,isoitnfandth1c,eecsQoon6fs1tphHiecumsoau...
共价RAS抑制剂及其用途.pdf-原创力文档

(ensartinib)(X‑396);洛拉替尼(lorlatinib);ASP3026;CEP‑37440;4SC‑203;TL‑398; PLB1003;TSR‑011;CT‑707;TPX‑0005和AP26113。ALK激酶抑制剂的其它实例描述于 W实施例3‑39中。 [0245]在一些实施方案中,抗癌剂是受体酪氨酸激酶(RTK)/生长因子受体下游成员的抑制剂(例如SHP2、SOS1抑制...