These data provide evidence that inhibition of RANKL, in this case by its natural inhibitor OPG, can have clinically measurable effects. However, the development of OPG as a therapy for osteoporosis was not pursued because of its potential immunogenicity, because immunologic resistance to OPG could ...
地舒单抗生物类似药 (Celltrion): 一种RANKL抑制剂药物,由Celltrion, Inc. (Celltrion, Inc.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: RANKL抑制剂(肿瘤坏死因子配体超家族成员11抑制剂),治疗领域: 肿瘤,内分泌与代谢疾病,皮肤和肌肉骨骼疾病,在研
In certain aspects, the composition is based on a polypeptide which includes the leading 215 amino acids of the human osteoprotegerin followed by the Fc portion of the human IgGl protein. Pharmaceutical formulations are provided that are suitable for administering the pharmaceutical composition into ...
Clinical and Expression data were downloaded from cbioportal and analyzed using Kaplan Meyer plots in SRplot (https://www.bioinformatics.com.cn/en) and GraphPad. We divided patients into those expressing high RANK and low LGR4 expression levels (RANKhigh/LGR4low), patients expressing low RANK ...
rsRANKL 重组可溶性RANK配体 品牌:O Yeast CAS No.: 储存条件:-80℃ 纯度:– 产品编号 (生产商编号) 等级规格运输包装零售价(RMB)库存情况参考值 303-52191 –20 ug–咨询–– * 干冰运输、大包装及大批量的产品需酌情添加运输费用 * 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因...
(2) to compare the efficacies of the blockade of RANKL/RANK interaction as well as the blockade of NF-κB inhibitor kinase (IKK) and of NF-κB translocation to the nucleus, also in comparison with glucocorticosteroid treatment, in terms of the development of a mouse model of allergic airway...
10.1210/en.142.4.1419. CAS PubMed Google Scholar Hikita A, Yana I, Wakeyama H, Nakamura M, Kadono Y, Oshima Y, Nakamura K, Seiki M, Tanaka S: Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappa B ligand. J Biol Chem. 2006, 281: 36846-...
Lewis rats with established AIA or CIA were treated for 10 days (from day 4 post onset) with either PBS (Veh), TNFα inhibitor (pegsunercept), IL-1 inhibitor (anakinra), or RANKL inhibitor (osteoprotegerin (OPG)-Fc). Local inflammation was evaluated by monitoring hind paw swelling. Bone...
Enjuanes等[33]研究显示,阿仑膦酸钠通过直接作用于成骨细胞和成骨前体细胞抑制骨吸收,达到治疗骨质疏松的目的;阿仑膦酸钠通过维生素D作用于成骨细胞前体细胞,使得RANKLmRNA表达增高,而OPG在成骨细胞前体细胞分化中未发生改变。Peng等[34]研究发现,锶在骨代谢过程中的破骨细胞和成骨细胞交叉串扰(cross-talk)效应中...
We further proved that the activation of NF-κB is crucial for RANKL/RANK signaling to regulate dγδ T polarization with the help of PDTC, a selective inhibitor of NF-κB. As shown in Fig. 5c, d, increased levels of TGF-β1 production and Foxp3 expression in dγδ T, which was co...