Nevertheless, RANKL-inhibitor therapies fail to consider the biological effects of disrupting RANKL binding to LGR4. While the role of the RANKL/RANK signaling pathway in stemness, tumor promotion, and metastasis have been thoroughly elucidated, the precise function of RANKL through its interaction ...
Treatment with glucocorticoids and the inhibitor of IKK prevented the OVA-induced increase in the absolute count of CD11b-CD103+CD11chigh (CD103+) DCs in the MLNs. However, it is not clear whether this effect was involved in producing the anti-asthmatic effect of both agents because some ...
RANKL/RANK axis functions through two different downstream signaling pathways: 1) the first pathway triggers activation of inhibitor-kB kinase(IKK)-α, resulting in proteasome degradation of IkBα (inhibitor of kappa Bα) and its dissociation from NF-kB, which migrates to the nucleus and ...
RANKL/RANK axis functions through two different downstream signaling pathways: 1) the first pathway triggers activation of inhibitor-kB kinase(IKK)-α, resulting in proteasome degradation of IkBα (inhibitor of kappa Bα) and its dissociation from NF-kB, which migrates to the nucleus and ...
It is a soluble protein that binds to RANKL, functioning as a competitive inhibitor of RANK activation. OPG has been found to be crucial in maintaining skeletal tissue homeostasis, as experiments involving constitutive overproduction have led to an osteopetrotic phenotype in mice while absence of ...
This increase was inhibited by pretreatment with sirtinol (20 μM) for 30 min, a SIRT1 inhibitor (Fig. 2E and F), indicating that cilostazol significantly enhanced the activity and expression of SIRT1. In immunofluorescence assessment, to verify the universality of this drug we identified the ...