While many modern clinical trials employ restricted, stratified or covariate-adaptive randomization designs that pursue balance in treatment assignments and balance across important covariates, some clinical trials call for response-adaptive or covariate-adjusted response-adaptive (CARA) randomization designs ...
Randomization, a fundamental feature of clinical trials design, is a process invoking the use of probability to assign treatment interventions to patients. In general, randomization techniques pursue the goal of providing objectivity to the assignment of treatments, while at the same time balancing for...
In recent times there has been an enormous growth in the number of randomized controlled trials (RCTs). Their importance for clinical practice is inarguable, so it is essential for the practitioner to acquire a basic knowledge of their methodology, in order to accurately evaluate this type of ...
Lachin, «Randomization in Clinical Trials: Theory and Practice» Wiley-Interscience | ISBN 0471236268 | 2002 Year | DjVu | 2,63 Mb | 288 Pages "…excellent for learning on how to use randomization ideas…" (Journal of Statistical Computation & Simulation, May 2004) "This book ...
knowing an upcoming treatment assignment in a sequence, may enroll a patient who, in their opinion, would be best suited for this treatment. Consequently, one of the groups may contain a greater number of “sicker” patients and the estimated treatment effect may be biased. Systematic covariate...
The “Methods” section provides some general background on the methodology of randomization in clinical trials, describes existing restricted randomization procedures, and discusses some important criteria for comparison of these procedures in practice. In the “Results” section, we present our findings...
aRandomizing study subjects into treatment arms for clinical trials can be a difficult and complex undertaking. Study subject bias can be introduced during randomization. Increasingly complex study designs and treatment scenarios complicate the process. Trident simplifies randomization and minimizes study sub...
Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practiceThe Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the ...
Randomization in clinical trials: stratification or minimization? The HERMES free simulation software OBJECTIVES: Operative clinical trials are often small and open-label. Randomization is therefore very important. Stratification and minimization are two ra... HF Chabouis,F Chabouis,F Gillaizeau… - ...
For multiple mutually exclusive strata, these tests are correlated. For this case, a combined covariate-adjusted test of treatment effect is described. Finally, we show how to generalize the urn design to a prospectively stratified trial with a fairly large number of strata. 展开 ...