inverse probability weightingCox regressioncovariate adjustmentsemiparametric theoryprojection theoremTwo‐stage randomization designs are broadly accepted and becoming increasingly popular in clinical trials fo
Epidemiology(发病率高),diagnosis(诊断困难,发现即晚期),treatment(覆盖率低因此预防很重要),prognosis(预后不好),disease burden...Then taken together,point out the importance and urgency for disease prevention ; Previous studies on the association between exposure and outcome(general to specific,experimental...
The causal effect between gut microbiota and infertility was primarily assessed using the random-effect inverse variance weighted (IVW) method. As a main analytical approach, IVW estimates were considered to be in a relatively ideal state, with their effectiveness relying on the validity of all ge...
Here, for the first time, we assessed the association of earlier puberty with sleep duration observationally and with validation using Mendelian Randomization. In the "Children of 1997" birth cohort (n=8,327), we used adjusted multivariable logistic regression to assess the associations of each ...
The inverse variance weighted method provided the main results. We utilized Cochran'sQ-test and Mendelian randomization-Egger regression to assess heterogeneity. Leave-one-out analysis was conducted to assess the impact of individual single nucleotide polymorphisms on the observed effect. Our analysis ...
Heterogeneity analyses was conducted using the MR-Egger method (Cochran'sQ=1.155;P=.764) and IVW (Cochran'sQ=1.356;P=.852) demonstrated no statistically significant heterogeneity among the selected SNPs. We employed MR-Egger regression (尾 intercept = 0.026; SE=0.058;P=.684) and the MR-...
Methods Using publicly available genome-wide association study datasets, bidirectional two-sample Mendelian randomization (TSMR) was performed using the inverse-variance weighted (IVW), weighted median, MREgger regression, simple mode, and weighted mode methods. Results The results of MR for the ...
SUA, serum uric acid; CAD, coronary artery disease; SNP, single-nucleotide polymorphism; CI, confidence interval; IVW, inverse variance-weighted. Discussion This is the first two-sample MR study to explore the association between SUA levels and risk of CAD among patients with diabetes. No ...
For palindromic SNPs, the forward strand was inferred where possible using allele frequency information, and alleles were harmonised based on matching alleles. Where ≥ 2SNPs were available, our primary MR method was inverse variance weighted (IVW) regression. We also conducted weighted median and ...
In addition to IVW, other methods including MR-Egger, weighted median, Simple mode, and Weighted mode were employed. MR-Egger regression was utilized to address horizontal pleiotropy, albeit with slightly reduced precision. Support for MR-Egger was determined if the effect estimate aligned with MR...