The pharmacokinetics and pharmacodynamics of single oral doses of 5 mg ramipril and 6 mg piretanide administered separately and in combination were determined in a single blind, randomised, 3-period cross-over study in 24 healthy male volunteers.The peak plasma concentrations of ramipril and ...
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Serum angiotensin converting enzyme activity was markedly suppressed for more than 24 hours after a single dose of 5 or 10 mg ramipril. No subjective or objective adverse effects were noted, and the tolerance to the drug was very good.
PD response to ramipril was evaluated on the change from period baseline in AUC0-24 in each period for the tetrapeptide N-Acetyl-Ser-Asp-Lys-Pro (AcSDKP) after 6 daily doses of 5 mg ramipril alone and under co-administration with lixisenatide.Dahmen R...
5 days prior to middle cerebral artery occlusion (MCAO) for 90 min with reperfusion. Groups (n = 10 each): (1) sham, (2) vehicle (V; 0,9% NaCl), (3) T (0,5 mg/kg once daily), (4) R (0,01 mg/kg twice daily), (5) R (0,1 mg/kg twice daily) or (6) T (0,5...
Ramipril dose titration was made in 1,5 weeks. The average daily dose of ramipril was 6,1 mg in the morning taking, and 5,0 mg in the evening taking. Results. 20 patients finished study completely. 24 hour initial level of systolic (SBP) and diastolic BP (DBP) was 141,5 +/- 1,...
The enhancement of citric acid-induced cough caused by ramipril (10mg/kg) was reduced by the kinin B 2 receptor antagonist MEN16132 (0.25mg/kg ip). BK and PGE2 levels in the BAL fluid were increased, in comparison to the control group, after ramipril treatment, while they were unchanged ...
Patients were randomized to receive ramipril 2.5, 5, or 10 mg, or enalapril 5, 1 0, or 20 mg once/day for 3 or 4 weeks. Measurements and Main Results. At baseline, supine diastolic blood pressures ranged from 98-116 mm Hg. Supine and standing systolic blood pressures were reduced by ...
METHODS: In a double-blind, randomized clinical trial with a 2-by-2 factorial design, we randomly assigned 5269 participants without cardiovascular disease but with impaired fasting glucose levels (after an 8-hour fast) or impaired glucose tolerance to receive ramipril (up to...
60 patients of stage II hypertension without having any other cause of microalbuminuria were selected as subjects for the present study and were randomly distributed in to 2 groups- Group A included 30 patients who were given Ramipril 5 mg/ day and Group B included the same number of patients...