Moreover, administration of ramipril increased the survival of old SHR and doubled the lifespan of young SHR.Carotid artery compliance and distensibility increased significantly in a double-blind, randomised study of patients with hypertension who were treated with ramipril 2.5 mg/day for 12 weeks;...
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After MI, rabbits in the RAM group were fed with intragastric ramipril(1 mg/kg per day) for 12 weeks. Before and 12 weeks after MI in the three groups, ventricular tachycardia or fi brillation(VT/VF) episodes and MAP in cadiocytes of the epicardium, mid-myocardium and endocardium were...
Seven rabbits fed the atherogenic diet received ramipril (3 mg/kg mixed into their food daily) and 6 rabbits were maintained on the atherogenic diet alone. Control rabbits (n = 6) were fed a standard diet and did not receive ramipril. At the end of the dietary intervention, the rabbits ...
Starting with 2.5 mg/day, the dose of Ramipril was increased to 5 mg and 10 mg at intervals of 5 days as long as diastolic blood pressure dropped below 90 mmHg. Twentyfour-hour blood pressure monitoring was performed before, 2 weeks, 6 weeks, and 12 weeks after ramipril therapy. Twenty...
Patients were randomized to receive ramipril 2.5, 5, or 10 mg, or enalapril 5, 1 0, or 20 mg once/day for 3 or 4 weeks. Measurements and Main Results. At baseline, supine diastolic blood pressures ranged from 98-116 mm Hg. Supine and standing systolic blood pressures were reduced by ...
In order to evaluate the pharmacokinetics and excretion of ramipril in man, 8 cholecystectomy patients aged between 53 and 68 years received 5 mg ramipril orally as a single dose. All patients had a T-drain inserted to permit bile collection; all gave their informed consent to participate in ...
Patients were randomized to receive ramipril 2.5, 5, or 10 mg, or enalapril 5, 10, or 20 mg once/day for 3 or 4 weeks.Measurements and Main Results. At baseline, supine diastolic blood pressures ranged from 98–116 mm Hg. Supine and standing systolic blood pressures were reduced by ...
The hemodynamic effects of a single dose of 5 mg of ramipril, a new angiotensin converting enzyme inhibitor, were investigated in 10 patients with chronic congestive heart failure. Arterial blood pressure and total peripheral resistance were decreased by approximately 12% without causing reflex ...