Raf-1 kinase inhibitor protein (RKIP) is an inhibitory molecule that down-regulates the effects of the Ras/Raf/MEK/ERK signaling pathway. The aim of this study was to examine the expression of RKIP and pRKIP in melanomas at different stages. We evaluated the RKIP and pRKIP protein by ...
Raf-1 kinase inhibitory protein (RKIP) was recently identified as a physiologic endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway. The expression and role of RKIP within the pancreas are unknown. RKIP expression in normal pancreas and human insulinomas was examined by ...
英文名称:Rat Raf-1 kinase inhibitor proteinelisa Kit 用途:用于科研实验使用 产地:深圳 品牌:瑞清 包装规格:96T 标记物:HRP 样本:血清.血浆.组织.相关液体等 检测方法:酶联免疫法 应用:仅供科研使用 检测限:详询 货号:RQ-sw12829 是否进口:否
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Raf激酶抑制蛋白 （Raf kinase inhibitor protein，RKIP ） 在乳腺癌、前列腺癌、肺癌等多种恶性肿瘤中 表达减少［5］，与Raf -1/MEK/ERK、G蛋白耦联受体、核因子κB （nuclear factor -kappa B）、Wnt等多种信号通路的调节有关，导致肿瘤进展及治疗抵抗［6］。本研究通过检测放射治疗前NSCLC...
摘要rkip(raf kinase inhibitor protein)是磷脂酰乙醇胺结合蛋白家族(phosphatidylethanolamine-binding proteins,pebps)的成员之一。研究发现,它能抑制ras/raf/mek/erk、nf-κb和g蛋白偶联受体激酶-2(grk-2)信号转导通路,从而在细胞的生长及恶性变中发挥重要的作用。 关键词rkip;信号转导;肿瘤 中图分类号q51文献标...
Raf-1激酶抑制蛋白RKIP结合底物Raf1的结构基础 Raf-1激酶抑制蛋白(Raf-1 kinase inhibitor protein,RKIP)通过与Raf-1激酶相互作用,调节Raf1/MEK/ERK信号通路。然而,RKIP与Raf1的结合机制不清楚。我们重组制备了RKIP和Raf11-147aa片段,并用GST-pull down实验验证了它们的相互作用。核磁滴定实验结果表明,... 郭晨云...
Background Raf-1 kinase inhibitory protein (RKIP) was recently identified as a physiologic endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway. The expression and role of RKIP within the pancreas are unknown. Methods RKIP expression in normal pancreas and human insulinomas ...