Background: The other side of radiotherapy (RT), in addition to the cytotoxic effect, is the ability to modulate the immune system in terms of activation or suppression, also depending on the dose and fractionation delivered. This immune RT effect can be detected both locally ...
This article shows the relationship between the dose per fraction of radiation, the effect on the immune system and the mechanisms for resistance. Article PubMed PubMed Central Google Scholar Fischer, J. C. et al. RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and ...
Synergistic effects are more likely to occur when immunotherapy is in combination with SBRT, which is associated with the stimulatory effect on immune system of high-dose, hypofractionated radiation [78]. It is prospective to achieve optimal results by utilizing synergistic effects of immunotherapy and...
Effect of radiotherapy on immune checkpoint molecules in the TME ICs are a class of immunosuppressive molecules that regulate the immune response. In the physiological state, ICs avoid tissue damage by regulating the persistence and intensity of the immune response. In contrast, tumor cells employ th...
The particles carried the target modulator, which further targeted the epitopes on immune cells, and direct or indirect antitumor action. b NPs extravasate into the tumor stroma through the fenestrations of the angiogenic vasculature, which can be enhanced by the EPR effect. c NPs have ability ...
A significant interaction would indicate nonadditivity and thus a synergistic relationship between the 2 treatments in their effect on these outcomes. The first approach treated the outcomes as count data, and Poisson regression models were used to assess the significance of interactions between 153-Sm...
resulting in recruitment and activation of Batf3-dependent dendritic cells. This effect is essential for priming of CD8+T cells that mediate systemic tumour rejection (abscopal effect) in the context of immune checkpoint blockade. Thus, Trex1 is an upstream regulator of radiation-driven anti-tumour...
the QD-Cat-RGD nanoprobes show a beneficial performance as a radiosensitizer with a high-Z atom (Pb) in the nanoprobe, which not only promotes the direct killing effect of cancer cells but also enhances the immunogenicity of cancer cells via ICD to trigger a robust antitumor immune response....
Evaluation of the effect of the radiation on the immune response and suggestion for postoperative radiotherapy. Cancer 1977;39:924-9Levitt S, McHugh R, Song C. Radiotherapy in the postoperative treatment of operable cancer of the breast. Part 1. Critique of the clinical and biometric aspects...
Besides its direct effect on the tumor vasculature, VEGF can also modulate the immune environment [117]. Several studies demonstrated that VEGF has the ability to inhibit the differentiation and function of diverse immune cells like dendritic cells, macrophages, and lymphocytes, respectively [118–120...