In addition, the “abscopal effect” may play a role in disease response outside of the radiated area. We review the current literature regarding the effects of ablative radiation therapy, the potential for immune modulation from it, and the mechanisms of the distant effects it elicits.Adam S...
This article shows the relationship between the dose per fraction of radiation, the effect on the immune system and the mechanisms for resistance. Article PubMed PubMed Central Google Scholar Fischer, J. C. et al. RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and ...
4.3.1.1Radiotherapy and its effect on the immune system As noted in the previous section,radiotherapydestroys the tumor locally, and this is done by destruction the DNA. Along with this local action that destroys the DNA of tumor cells, radiotherapy can cause changes in the immune response again...
However, RT doesn’t work the way we want it to, on the contrary, the immunomodulatory effect induced by RT is a double-edged sword that not only enhances systemic antitumor immune response but also promotes immunosuppression to some extent.35,98Generally, IR is deemed to inhibit the immune ...
Furthermore, previous studies have shown that DNA damage caused by radiotherapy significantly induced the expression of NKG2D ligands on tumor cells, which enhanced the anti-tumor activity of NK cells [10]. Therefore, radiotherapy may enhance the anti-tumor effect of CAR-NK cells by improving the...
Nevertheless, the overall stimulating influence of irradiation on the immune system has been recognized and illustrated in preclinical studies as well as clinical case reports. There have been several attempts to use radiotherapy as an in situ vaccine. The basic rationale is a synergistic effect of ...
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view of RT as a simple local treatment has dramatically changed in recent years, and it is now widely accepted th...
effect is not yet completely understood. Therefore, in this review, we describe the anti-tumor effect of RT and immune checkpoint blockade and discuss several publications on the abscopal effect of combination therapy, primarily to define the potential predictors of this effect so that the ...
Effect of radiotherapy on immune checkpoint molecules in the TME ICs are a class of immunosuppressive molecules that regulate the immune response. In the physiological state, ICs avoid tissue damage by regulating the persistence and intensity of the immune response. In contrast, tumor cells employ th...
In the era of cancer immunotherapy, there is a high interest in combining conventional cancer therapies such as radiotherapy with drugs that stimulate the immune system. The observation that ionizing radiation applied to mouse tumors could delay the growth of distant lesions ("abscopal effect") and...