A therapy for skin conditions, including psoriasis, eczema and vitiligo, that is composed of a plant-derived ultraviolet (UV)-sensitizer compound (psoralen), combined with UVA radiation (long wavelength radiatio
Radiation therapy (RT) has historically been the most common approach used to achieve local tumor control in cancer patients. However, emerging evidences over the last decades suggest an important role for RT in modulating or amplifying the antitumor immune response upon induction of cancer cell ...
Radiation therapyuses high-energy radiation to kill cancer cells. Radiation normally induces the production of cellularreactive oxygen species(ROS), which in turn releasesfree radicalsthat damage cellular DNA. Radiation therapy can damage both normal and cancer cells. Therefore, treatment must be careful...
This reference demonstrates that BRCA2 limits the ability of CHEK1 activation by radiation therapy to promote the exposure of PD-L1 on the membrane of cancer cells, hence preventing them from driving T cell exhaustion. Article PubMed PubMed Central CAS Google Scholar Vendetti, F. P. et al....
Intraoperative radiation therapy— Radiation is delivered to a tumor during surgery. Radiosensitizers— These drugs increase radiation's damaging effect on cancer cells. Radioimmunotherapy— Radioactive substances are attached to antibodies, defensive chemicals made by the body's immune system. These antibo...
Abbreviations: 3-D CRT = 3-dimensional conformal radiation therapy; AJCC = American Joint Committee on Cancer; chemo = chemotherapy; ES = extensive-stage; fx = fractions; IMRT = intensity modulated radiation therapy; KQs = key questions; LS = limited-stage; MRI = magnetic resonance imaging; ...
Cancer cells continue dying for weeks to months after radiation therapy ends. This delayed effect applies to healthy cells too, which can explain why some side effects take time to manifest. Rapidly dividing cells, such as those of the skin, bone marrow, and intestinal lining, are often the ...
Since H@Gd-NCPs sensitized radiation could effectively induce ICD and activate immune responses against primary and distant CT26 colorectal tumors, we went on to determine the anti-metastatic effect in a spontaneous 4T1 metastatic breast cancer model (Fig. 9a). Compared with radiation therapy alone...
and act to weaken the therapeutic effect of RT. The quantity of preclinical experiments aimed at restoring antitumor immune responses through CAF-targeted therapy has expanded substantially in recent years. Different therapeutic approaches are under investigation, including targeting of specific CAF functiona...
Stereotactic body radiation therapy for operable early-stage lung cancer. JAMA Oncol. 2018. https://doi.org/10.1001/jamaoncol.2018.1251. Article Google Scholar Tsoutsou PG. The interplay between radiation and the immune system in the field of post-radical pneumonitis and fibrosis and why it is...