Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute RIII is essentially symptomatic and nutritional...
Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury Intestine is a highly radiation-sensitive organ that could be injured during the radiotherapy for pelvic, abdominal, and retroperitoneal tumors. However, t... H Lu,H Yan,Li, XiaoyuXing, YuanYe, YumengJiang,...
a2-Iminodihydrocoumarins and 2-Iminocoumarins 2-Iminodihydrocoumarins和2-Iminocoumarins [translate] aMulti-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury 人的脂肪性获得的mesenchymal干细胞的多治疗作用在幅射线导致的小肠伤害 [translate] ...
[translate] aMulti-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury 人的脂肪性获得的mesenchymal干细胞的多治疗作用在幅射线导致的小肠伤害 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 葡萄牙语翻译 ...
We found that irradiatedmice show decreased villous height, crypt depth, crypt to villi ratio and expression of the proliferation marker, proliferating cell nuclear antigen, indicative of intestinal injury.mice show increased expression of the pro-inflammatory cytokines () and chemokines (,,) andin ...
Radiation-induced intestinal injury (RIII) is a common and significant side effect of abdominal or pelvic radiotherapy [59]. The small intestine is among the most radiosensitive organs in the body [58,60], though injury can be sustained throughout the GI tract. Understanding novel mechanisms of...
Mechanism of ferroptosis mediated radiation-induced intestinal injury. Credit: Nie Lili According to research published recently inRedox Biology, a team led by Prof. Han Wei from Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS) found, for the first time, that dieta...
By using ferroptosis inducer RSL-3 and inhibitor liproxstatin-1, we found that ferroptosis is essential for IR-induced intestinal injury. Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) is an important component for ferroptosis execution, and we found that ACSL4 expression was significantly...
Metformin protects mice from radiation-induced intestinal injury by regulating AMPK-NRF2-dependent mitophagy [15]. Researchers have developed a long-term stable Pickering emulsion containing vitamin E by growing CeO2 in situ on nanotubes and loading the ferroptosis inhibitor deferiprone within the lumens...
Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic dev