GlioblastomaApoptosisRadiotherapy remains one of the cornerstones of treatment of patients with gliomas. Radiationinduced damage to DNA can result in the loss of proliferative capacity of neoplastic cells. In addition to mitotic cell death, it has recently been found that other cellular events can ...
HF60 constitutes a safe RT approach that shows survival comparable to standard RT while allowing for a shorter treatment time. 展开 关键词: Glioblastoma Radiation Hypofractionation Temozolomide MGMT DOI: 10.1186/s13014-015-0396-6 被引量: 18 年份: 2015 ...
[Use of the functional imaging modalities in radiation therapy treatment planning in patients with glioblastoma] Dhermain F; Duereux D; Bidauh F;.Use of the functional imaging modalities in radiation therapy treatment planning in patients with glioblastoma.Bull ... F Dhermain,D Ducreux,Franois ...
Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas Glioblastomas are lethal brain tumors that are treated with conventional radiation (X-rays and gamma rays) or particle radiation (... Todorova,K Pavlina,Fletcher-Sananikone,... - Cancer Re...
ObjectiveStem cells residing in the subventricular zone (SVZ) may be related to recurrence, potentially affecting outcome in glioblastoma (GBM). This study investigated the relationship of SVZ radiation dose and survival in a large cohort treated with surgery and chemoradiotherapy (CRT).MethodsPatients...
This energy allows the treatment of a tumour located at the centre of the human brain (i.e., the worst scenario). This setup enabled the lateral irradiation of rat brains in the plateau region. The dose rate was 2 Gy/min at a 1-cm depth. For minibeam generation, a multislit brass...
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Phase II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multi... Only 8.4% (7 of 83) of patients had clinically documented therapy-associated neurotoxicity ("radiation necrosis"). When comparable selection criteria...
SRS is well tolerated in the treatment of glioblastoma. As there was no difference in survival whether SRS is delivered upfront or at recurrence, the treatment for each patient should be individualized. Future studies are needed to identify patients most likely to respond to SRS. ...
The current gold standard treatment for glioblastoma (GBM, World Health Organization [WHO] grade IV) is maximum safe tumor resection, followed by concurrent chemoradiotherapy (CCRT) with temozolomide1,2. In cases of elderly patients with unmethylated 6-methylguanine-DNA methyltransferase (MGMT) promoter...