Pharmacologic inhibition of HIF-2α improved bone integrity; however, systemic treatment caused off-target effects. Therefore, a bone-targeting nanocarrier was developed to deliver localized HIF-2α inhibition, which alleviated radiation-induced bone loss without systemic off-target...
Irradiation of bone kills the cells that are responsible for bone maintenance and remodeling that renders the irradiated bone brittle and prone to injury. Though the incidence of bony injury has becom MA Engleman,G Woloschak,W Small - 《Cancer Treatment & Research》 被引量: 13发表: 2006年 ...
The inhibitory effects of DHLA treatment were comparable to DP except for the apparent suboptimal effect of DHLA to inhibit Tnf-α expression. Ibuprofen only mitigated the expression of Nfe2l2, Mcp1 and Opg. Surprisingly, the AOX diet did not prevent the changes in gene expression caused ...
Complex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival. In the context of bone metastases radiotherapy, low rates of treatment close to the end of life, e.g.
leading to infertility [148]. The extent of the damage caused by radiation depends on the dosage and exposure methods (radiotherapy alone or in combination with other treatment methods). Since spermatogonia are mitotically active, the dividing spermatogonia are most vulnerable to radiation treatment [...
Wound healing is a complicated process that includes inflammation, proliferation, regeneration, and remodeling, involving interactions among a variety of cells, chemokines, cytokines, growth factors, and extracellular matrix1. Radiotherapy plays a critical curative role in the comprehensive treatment of a ...
Treatment of whole body irradiation becomes more complicated with numerous adjunctive medications that may be useful, including KI, diethylenetriaminepentaacetate (DTPA), Prussian blue, and Neupogen. Such patients should be considered to be immunocompromised and treated as such. There is an excellent ...
TREATMENT OF RADIATION LESIONS OF THE RECTUM BY INJECTION OF MEDICAL AGENTS IN THE PRESACRAL REGION 来自 ResearchGate 喜欢 0 阅读量: 10 作者: Lubenets 关键词: n48510* --life sciences--radiation effects on animals--man female genitals hydrocortisone injection ionizing radiations mixtures ...
Ionizing radiation (IR) has played a crucial role in cancer therapy ever since Maria Sklodowska-Curie and Antoine Henri Becquerel discovered its physiological effects in 1901 [1]. Today, approximately 50% of cancer patients undergo radiation treatment [2,3,4,5,6]. However, radiation therapy come...
Radiation therapy for glomus tumors of the temporal bonedoi:10.1016/S1808-8694(15)31244-1radiotherapyearhearinglossparagangliomaquemodectomaSummary The treatment of glomic tumors has been controversial since its first description. It can be done with surgery, radiotherapy or just expectation. Aim The ...