Radiotherapy, one of the clinical treatments of cancer, is accompanied by a high risk of damage to healthy tissues, such as bone loss and increased risk of fractures. The aim of the present study was to establish a rat model of local and systemic bone injury by focal irradiation, in order...
An open head injury usually results from penetrating brain damage (e.g., from a shooting incident or use of another weapon) but can also arise from a tearing of the dura (e.g., with ventricular fistula following basal skull fractures). An additional categorizatation of the morphology of ...
242 Vitamins K1 and K2 protect osteoblasts from H2O2-induced oxidative damage, suggesting a protective role of vitamin K in the mineralization, formation and remodeling of bones.243 Inhibiting p66Shc decreases oxidative stress and promotes osteogenesis, which can be repressed by E2 and DHT (Fig. ...
This swelling could cause a build-up of pressure under the cast, yielding increased pain and the potential for damage to the tissues under the cast. However, if the fracture required reduction (putting the bones back into alignment) there might be a need for the circumferential cast to keep ...
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the accommodation of bones to dynamic mechanical f
The differential diagnosis includesosteoporosis,degenerative disease, andPaget disease. The isotopebone scanis a sensitive test to detect the presence of skeletal pathology but gives little information about its nature. Structural information on skeletal damage from metastaticbone diseaseis best obtained by...
While autologous bone grafting is the preferred treatment option for a severe bone defect, it does have some drawbacks, including limited supply, donor-site morbidity, and additional damage to the patient5. On the other hand, although allogeneic bone grafts are widely accessible, they have a ...
The deleterious effects of X-rays on bone have been recognised for almost a century and continue to be seen today because of improved survival in patients treated for malignancy with radiotherapy with or without other treatments. In this pictorial review we present the imaging features of radiation...
Transplants of bone marrow or stem cells can be used to treatanemia, leukemia, and otherblood disorders. When the immune system is severely weakened by chemotherapy or radiation treatments for cancer, bone marrow transplants create new whiteblood cells(Alcoser & Burchett, 1999). ...
Pursuant to the present invention, the ameliorating of symptoms that result from growth of bone-metastasizing cancer and bone-originating cancer, by administering a PTH receptor agonist, may be implemented in conjunction with conventional cancer treatments, such as chemotherapy, surgery, and radiation. ...