Radiation-induced brain injury (RBI) presents a significant challenge for patients undergoing radiation therapy for head, neck, and intracranial tumors. This review aims to elucidate the role of ferroptosis in RBI and its therapeutic implications. Specifically, we explore how ferroptosis can enhance the...
In this review, historical and current clinical evidence on the age dependency of radiation-induced neurocognitive dysfunction is summarized. Moreover, recent research developments regarding the mechanistic causes for this age-related extent of brain damage following IR exposure are presented. C...
Radiation-induced brain injury can damage neuronal, glial and vascular compartments of the brain and may lead to molecular, cellular and functional changes. Given its central role in memory and adult neurogenesis, the majority of studies have focused on the hippocampus. These findings suggested that...
In patients with nasopharyngeal cancer (NPC), radiation-induced temporal lobe injury (TLI) is the most dreaded late-stage complication following radiation therapy (RT). We currently lack a definitive algorithmic administration for this entity. In the mea
PPAR agonists have been shown to cross the blood-brain barrier and confer neuroprotection in animal models of CNS disorders such as stroke, multiple sclerosis and Parkinson's disease. However, the role of PPARs in radiation-induced brain injury is unclear. In this manuscript, we review the ...
Radiation-induced brain injury: A review. Front Oncol. 2012;2:73. Monje ML, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural precursor-cell dysfunction. Nat Med. 2002;8:955–62. Article CAS PubMed Google Scholar Monje ML, Palmer T. Radiation injury and neurogenesis. Curr ...
Microglia are the resident immune cells and the professional phagocytic cells of the CNS, showing a multitude of cellular responses after activation. However, how microglial phagocytosis changes and whether it is involved in radiation-induced brain injur
radioactive brain injury, hippocampal neuron, PI3K/Akt/mTOR signaling pathway, oxidative stress References [1] Balentova S, Adamkov M. Molecular, cellular and functional effects of radiation-induced brain injury: a review[J]. Inter J Mol Sci, 2015, 16(11): 27796 – 27815. DOI: 10.339...
Molecular, cellular and functional effects of radiation-induced brain injury: a review. Int J Mol Sci. 2015;16(11):27796–815. Article Google Scholar Chen YP, Chan A, Le QT, et al. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64–80. Article PubMed Google Scholar Semenenko VA, ...
Cell replacement therapy holds great promise as first animal studies using transplantation of neural stem cells to irradiated brain have been successful in restoring memory and cognition deficits. This review summarizes the epidemiological and biological data on radiation-induced brain damage and describes ...