Purpose:This project aimed to develop a stereotactic radiosurgery mouse model of radiation-induced brain injury to study endothelial damage within the neurovascular unit (NVU). Classification of focal endothelial damage and the resulting inflammatory cascade has never been cataloged for assessing intrinsic...
1991 Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial Clinical Kampinga HH 2006 Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field Review Finley DS, Pouliot...
induced by consecutive cycles does not apply to OFUS, because the single cycle stimulation of OFUS would be too short to form a stable gas bubble and keep it oscillating to perturb the ion channels. The radiation force is another plausible explanation believed to dominate high-frequency ultrasoun...
This technology has the potential to enhance delivery of various kinds of therapeutic agents into the brain and has potential to benefit treatment of CNS diseases. A growing number of applications have been developed for the use of therapeutic ultrasound in preclinical investigation, such as neuro...
The result is a therapeutic lesion generated using neither a skin incision, nor the insertion of a probe into the brain, nor ionizing radiation (Medel et al., 2012). The first report on the successful use of MRgFUS in the context of functional surgery reported on the safe creation of ...
using polycapillary X-ray optics to deliver focused kilovoltage (kV) radiation. The approach, described inMedical Physics, enables personalized conformal radiotherapy and spares critical structures in the eye, with potential to make AMD treatment more effective, less costly and more convenient for ...
Intensity values were confirmed by radiation force balance measurements. Using targeting images, approximately 20 foci in the LV and septum were treated with pFUS using the following US parameters: pulse length, 10 ms; duty cycle, < 1%; 100 pulses/site (Fig. 1d). Prior to pFUS, animals ...
5G will require cell antennas every 100 to 200 meters, exposing many people to millimeter wave radiation. 5G also employs new technologies (e.g., active antennas capable of beam-forming; phased arrays; massive inputs and outputs, known as MIMO) which pose unique challenges for measuring exposur...
The blood brain barrier (BBB) is a major obstacle to the delivery of therapeutics to the brain. Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles a
Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model Br J Radiol, 80 Spec (1) (2007), pp. S49-S55 Google Scholar Muro and Muzykantov, 2005 S. Muro, V.R. Muzykantov Targeting of antioxidant and anti-...