Finally, when the distomer is converted to the eutomer in vivo—as seen above for ibuprofen and its analogs—it also becomes preferable to commercialize the racemate. Box 18.1 The Water-Soluble d, l-lysine Salt of Aspirine: A Success Story Based on Luck and Serendipity Before World War II...
solubilitypolymorphismthermal analysisX-ray powder diffractionThe aim of this study was to investigate the solid dispersion phase behavior of s- or rs-ibuprofen in stearic acid. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary ...
Valentine Bebecca.Enantiomeric Resolution of Racemic Ibuprofen in Supercritical Carbon Dioxide Using a Chiral Resolving Agent. . 2002Valentine R. Enantiomeric resolution of racemic ibuprofen in supercritical carbon dioxide using a chiral resolving agent. PhD Dissertation, University of Pittsburgh, 2002....
(+)-(S)-Ibuproxam, a prodrug of (+)-(S)-ibuprofen, the pharmacologically active component of ibuprofen, was synthesized in order to minimize side effects (especially gastric irritation) and reduce effective dose. The low water solubility of (+)-(S)-ibuproxam, which prevents rapid ...
In this thesis, we focused on the crystallization of the racemic compound of (R,S)-(卤)-sodium ibuprofen dihydrate. It has three sections in this study. Firstly, a useful engineering data bank of solubility, polymorph, crystallinity and crystal habits of racemic (R,S)-(卤)-sodium ibuprofen...
Racemic ibuprofen (IBU) supercooled liquid has been detected using differential scanning calorimetry and powder X-ray diffraction during the melt-quenching of IBU at a low temperature (0 掳C). In this work, gram-scaled IBU supercooled liquid was prepared using the melt-quenching method, ...
Racemic ibuprofen (IBU) supercooled liquid has been detected using differential scanning calorimetry and powder X-ray diffraction during the melt-quenching of IBU at a low temperature (0 掳C). In this work, gram-scaled IBU supercooled liquid was prepared using the melt-quenching method, ...
Racemic ibuprofenscCOSilica carrierβ-CyclodextrinDissolution behaviorBioavailabilityThe poor aqueous solubility of ibuprofen due to its hydrophobicity limits the bioavailability of the drug in the aqueous environment of the human body…[ Sarah Reiser
Racemic ibuprofen (IBU) supercooled liquid has been detected using differential scanning calorimetry and powder X-ray diffraction during the melt-quenching of IBU at a low temperature (0 掳C). In this work, gram-scaled IBU supercooled liquid was prepared using the melt-quenching method, ...
Racemic ibuprofen (IBU) supercooled liquid has been detected using differential scanning calorimetry and powder X-ray diffraction during the melt-quenching of IBU at a low temperature (0 掳C). In this work, gram-scaled IBU supercooled liquid was prepared using the melt-quenching method, ...