高剂量组大鼠海马组织病理损伤依次缓解,脑组织含水率,脑梗死面积,神经细胞凋亡指数,IL-1β含量,TNF-α含量,IL-6含量及Rac1和NOX2蛋白表达水平依次降低(P <0.05);盐酸纳美芬高剂量组与地塞米松组新生大鼠各项指标差异无统计学意义(P>0.05).结论盐酸纳美芬可能通过抑制Rac1/NOX2通路,减轻HIE新生大鼠海马组织炎症...
NOX2,MAPK及NF-κB信号通路的活化.结果:葡萄糖剥夺导致661W细胞内ROS,氧化应激标志物HO-1水平升高,细胞活性降低,凋亡率增加,通过使用抑制剂NSC/APO阻断RAC1/NOX2通路可以保护损伤的661W细胞.葡萄糖剥夺导致NOX2核心亚基gp91,促凋亡蛋白Bax,细胞凋亡相关蛋白Caspase3表达水平增加,抗凋亡蛋白Bcl-2表达水平下降,线粒...
3.13.1 筛选浓度确定 3.13. 2 hsa_circ_0006602 siRNA稳转株鉴定 3.14裸鼠成瘤实验 3.15统计学分析 4 实验结果 4.1 骨肉瘤中hsa_circ_0006602的筛选与结构鉴定 4.1.1 hsa_circ_0006602 的环化过程 4.1.2 hsa_circ_0006602 的结构鉴定 4.2 骨肉瘤及癌旁组织中hsa_circ_0006602、miR-224和Rac1的表达 4.3 骨...
此外,激活miRNA-142-3p还能通过减少神经元凋亡及线粒体活性氧的生成,稳定线粒体膜电位,增加线粒体DNA的含量,保留线粒体呼吸链复合物以及抑制NOX2的激活等方式显著改善线粒体功能。最后,使用生物信息学技术确认了Rac1是miRNA-142-3p的作用靶点,miRNA-142-3p可通过负调控Rac1的表达,发挥有效的神经保护作用。 这项...
此外，激活miRNA-142-3p还能通过减少神经元凋亡及线粒体活性氧的生成，稳定线粒体膜电位，增加线粒体DNA的含量，保留线粒体呼吸链复合物以及抑制NOX2的激活等方式显著改善线粒体功能。最后，使用生物信息学技术确认了Rac1是miRNA-142-3p的作用靶点，miRNA-142-3p可通过负调控Rac1的表达，发挥有效的神经保护作用。...
(Nox).21,22 In our previous study, we found that Jak2/STAT3 was activated in amino-acid- and serum-deprivated cancer cells, as well as rapamycin-treated cancer cells.14 The activation of JAK2/ STAT3 was totally dependent on reactive oxygen species produced by NADPH oxidase enzymes that ...
肿瘤基因芯片吞噬双酚a卵巢肿瘤单体gtp结合蛋白质类协同作用免疫组织化学克隆低功率激光照射他莫昔芬二烯丙基二硫乳腺癌下丘脑腹内侧核δ-cateninαb-晶体蛋白wnt信号转导通路wnt5atiamlshrnarhoa和rac1/cdc42rhoarac1基因rac1-adf/cofilin1通路rac1gtp结合蛋白nsc23766nprapmda-mb-231人乳腺癌细胞cdc42cd151基因 ...
Nox1, Nox2, and NADPH oxidase activity are upregulated in spinal cord microglia from genetic mouse models of ALS and ALS patients and previous studies have demonstrated that either genetic deletion or chemical inhibition of Nox1 or Nox2 can slow disease progression and improve survival in ...
APE1 is a negative regulator of oxidative stress in the gastrointestinal epithelium during bacterial infection by modulating Rac1 and Nox1. Our results implicate APE1 in novel molecular interactions that regulate early stress responses elicited by microbial infections. 展开 ...