炎症反应目的 探讨樟芝多糖(ACP)通过抑制活性氧(ROS)-NADPH氧化酶2(NOX2)-NLRP1信号减轻皮层神经细胞(CNC)炎症损伤的作用和机制.方法 在研究ACP抗炎症反应作用的实验中,将CNC分为对照组,脂多糖(LPS)组,ACP 5 mg/L组,ACP 10 mg/L组和ACP 20 mg/L组.对照组为常规培养的细胞,无LPS和ACP干预;LPS组用0.1 ...
目的 研究人参皂苷Rg1在PC12细胞缺氧再复氧损伤中的作用及可能的机制.方法 将PC12细胞随机分6组,除空白对照组外,其余各组均缺氧缺糖6 h,再复氧复糖24 h制作OGD/R模型,各药物组均在造模前2 h给予相应药物预处理.采用DCFH-DA法检测细胞ROS生成,Annexin V-FITC/PI双染法检测细胞凋亡率,ELISA法检测细胞上清中...
Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells[J] . Xiaolan Wang,Guangpin Chu,Zhihua Yang,Yinan Sun,Hanjing Zhou,Man Li,Jing Shi,Bo Tian,Chun Zhang,Xianfang Meng.Toxicology . 2015Wang X, Chu G, Yang Z, Sun Y, Zhou H, Li M, Shi J, Tian ...
Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells[J] . Xiaolan Wang,Guangpin Chu,Zhihua Yang,Yinan Sun,Hanjing Zhou,Man Li,Jing Shi,Bo Tian,Chun Zhang,Xianfang Meng.Toxicology . 2015Wang X, Chu G, Yang Z, Sun Y, Zhou H, Li M, Shi J, Tian ...
In the present study, we investigated the effects of Rg1, tempol (ROS scavenger) and apocynin (NOX inhibitor) treatment for 9 weeks on cognitive performance, neuronal damage, and NOX2 and NLRP1 inflammasome expressions in 8-month old SAMP8 mice. The results showed that Rg1 alleviated ...