Oxidative stress, neuroinflammation, and Ca 2+ overload are regarded as important factors influencing AD. NADPH oxidase 2 (NOX2) and the NOD-like receptor family protein 1 (NLRP1) inflammasome play important roles in promoting oxidative stress and inflammation in neurons. Ca 2+ overload can ...
目的 研究人参皂苷Rg1在PC12细胞缺氧再复氧损伤中的作用及可能的机制.方法 将PC12细胞随机分6组,除空白对照组外,其余各组均缺氧缺糖6 h,再复氧复糖24 h制作OGD/R模型,各药物组均在造模前2 h给予相应药物预处理.采用DCFH-DA法检测细胞ROS生成,Annexin V-FITC/PI双染法检测细胞凋亡率,ELISA法检测细胞上清中...
NLRP1炎症小体目的 研究人参皂苷Rg1在PC12细胞缺氧再复氧损伤中的作用及可能的机制.方法 将PC12细胞随机分6组,除空白对照组外,其余各组均缺氧缺糖6 h,再复氧复糖24 h制作OGD/R模型,各药物组均在造模前2 h给予相应药物预处理.采用DCFH-DA法检测细胞ROS生成,Annexin V-FITC/PI双染法检测细胞凋亡率,ELISA...
Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells[J] . Xiaolan Wang,Guangpin Chu,Zhihua Yang,Yinan Sun,Hanjing Zhou,Man Li,Jing Shi,Bo Tian,Chun Zhang,Xianfang Meng.Toxicology . 2015Wang X, Chu G, Yang Z, Sun Y, Zhou H, Li M, Shi J, Tian ...
In the present study, we investigated the effects of Rg1, tempol (ROS scavenger) and apocynin (NOX inhibitor) treatment for 9 weeks on cognitive performance, neuronal damage, and NOX2 and NLRP1 inflammasome expressions in 8-month old SAMP8 mice. The results showed that Rg1 alleviated ...