This silences endogenous (selfish) retroelements and repetitive sequences in the Drosophila germ line. rasiRNA (24–29 nucleotides) is produced primarily from the antisense strand of the double-strand precursor unlike siRNA , which is made of both strands. rasiRNA does not require Dicer -1 or...
Repeat associated small interfering RNA (rasiRNA) is a class of small RNA that is involved in the RNA interference (RNAi) pathway. RasiRNA is a subclass of Piwi-interacting RNAs (piRNAs), which are small RNA molecule which interact with Piwi proteins. Piwi proteins are an Argonaute subfamily...
然而,由于缺乏靶向肝外器官或特定细胞的核酸载体,siRNA药物的开发仍局限于基于GalNAc修饰介导的肝实质细胞靶向递送。因此,开发新型核酸纳米递送载体,将RNA药物高效递送至激活的肝星状细胞(aHSCs)中,通过阻断异常上调的白细胞介素-11(IL-11)及其受体(IL11ra1),修复受损的肝组织,有望成为治疗NASH及相关肝纤维化的新...
The upregulation of transposable elements and tandem repeats in the germline of zuc and squ mutants pointed to a role for the Zuc and Squ proteins in the rasiRNA pathway. Hence, we sought to determine whether these proteins are involved in the biogenesis of the rasiRNAs or rather in the me...
IL-1β siRNA(siIL-1β)是一种特异性的小干扰RNA,旨在靶向并沉默IL-1β基因,从而调节炎症反应并可能用于治疗与炎症相关的疾病。聚合物-脂质杂化纳米颗粒(FS14-NP)是一种创新的药物递送系统,结合了聚合物和脂质的优点,以提高药物的稳定性、靶向性和细胞摄取效率,广泛应用于基因和小分子药物的递送。负载IL-1β...
NIRRA、Azzam - Akankah Sirna 专辑: Kenangan Berlalu 歌手:NIRRAAzzam 还没有歌词哦NIRRA、Azzam - Akankah Sirna / 已添加到播放列表 2 播放队列/2 1 Akankah Sirna NIRRA、Azzam 03:30 2 不停的陀螺 蔡小虎 03:59Mac版酷狗音乐已更新 就是歌多 ...
TAKlsiRNA基因沉默对RA滑膜细胞ATF2 表达的影响 目的 要求培养滑膜原代细胞,制备良好的转染剂,然后将转染液导入滑膜细胞内, 抑制人类风湿性关节炎滑膜细胞TAKl基因,给予体外刺激因素干预,检测ATF2 表达量,为人类风湿性关节炎的治疗及研究提供基础及依据。
微流控技术分别将三重siRNA序列包载于脂质纳米颗粒内.测量三重siRNAs LNPs的粒径并采用透射电子显微镜观察外观,测定包封率和载药量.通过剂量和时间两个方面,进行体内实验,筛选出最佳的给药条件.(2)三重siRNAs LNPs对亚急性酒精性肝病和慢性酒精性肝病的治疗效果.分别构建亚急性ALD和慢性ALD小鼠模型,慢性模型分3个...
Small interfering RNA (siRNA) is a promising tool for the treatment of dominant diseases. Autosomal dominant eye diseases like retinitis pigmentosa are a leading cause of blindness. Mutations in rds/peripherin lead to the degeneration of photoreceptors a
专利名称:抑制人RabJ基因表达的siRNA及其应用的制作方法 技术领域: 本发明属于生物技术和医学领域。具体而言,本发明涉及一种针对癌基因RabJ的表达及功能的干扰RNA核苷酸序列,该干扰RNA核苷酸序列具有靶向性抗肿瘤细胞RabJ基因表达及功能、抑制肿瘤细胞生长、抑制肿瘤细胞的致瘤性和促进肿瘤细胞凋亡的功能,从而起到治疗肿瘤...