RMC-7977是一种具有广泛活性的可逆三元复合物(RAS inhibitor)抑制剂,针对活跃状态下的突变型和正常型KRAS、NRAS和HRAS变体(RAS variants)。通过形成与CYPA(Cyclophilin A)的二元复合物(binary complex),RMC-7977能有效地阻断RAS与下游效应物的相互...
本文介绍十月份文献发表的RAS(MULTI)抑制剂,MCL-1 抑制剂,GSPT1降解剂,NLRP3炎症体抑制剂四种活性分子及其合成路线。 1RAS Inhibitor A122 RMC-6236是一种RAS(MULTI)抑制剂,通过抑制多种RAS癌症驱动因子的(ON)或活性形式,可以靶向多种常见的RAS致癌变体,支持其作为单药疗法用于携带RAS突变的NSCLC或PDAC患者的开发。
RAS inhibitor Abd-7 MCE 国际站:RAS inhibitor Abd-7 品牌:MedChemExpress (MCE) 货号:HY-122862 CAS:2351843-48-4 纯度:99.16% 存储条件:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year 运输条件:美国大陆的室温;其他地方可能有所不同。 产品活性:RAS inhibito...
K-Ras(G12C)抑制剂(K-Ras(G12C) inhibitor 12) 价格￥3800￥3610￥3420 起批量≥1瓶≥5瓶≥10瓶 最小起订1瓶 供货总量257瓶 发货地址北京市海淀区 建议售价￥5700/瓶 更新日期2025年01月22日 产品规格1mL(10mM)|2mg|5mg|10mg|50mg 即时洽谈立即询价查看联系方式 ...
英文同义词RAS INHIBITORY PEPTIDE;VPPPVPPRRR-NH2;VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG;H-VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-OH;HSOS (1149-1158) N10 SH3 BINDING DOMAIN;Sos SH3 domain inhibitor;L-Arginine, L-valyl-L-prolyl-L-prolyl-L-prolyl-L-valyl-L-prolyl-L-prolyl-L-ar...
中文名称:K-Ras(G12C)抑制剂(K-Ras(G12C) inhibitor 12) 英文名称:K-Ras(G12C) inhibitor 12 产品规格:1mL(10mM)|2mg|5mg|10mg|50mg K-Ras(G12C)inhibitor12是K-Ras(G12C)抑制剂,K-Ras(G12C)inhibitor12作用于H1792细胞,EC50为0.32μM。
RAS inhibitorThe invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
19. Jongs N, Chertow GM, Greene T, et al. Correlates and consequences of an acute change in eGFR in response to the SGLT2 inhibitor dapagliflozin in patients with CKD[J]. J Am Soc Nephrol. 2022;33(11):2094‑2107. 20...
EDTA-free protease inhibitor, 0.1 mg/ml lysozyme and 10 U/ml Benzonase nuclease. The lysate was centrifuged at 12,000×gfor 20 min then applied to Ni-NTA resin. Proteins were eluted using 20 mM Tris-HCl pH 8; 500 mM NaCl; 300 mM Imidazole; 5% Glycerol and dialyzed into...