参考文献: 【1】Doman JL, Raguram A, Newby GA, Liu DR. Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nat Biotechnol 38, 620-628 (2020).
参考文献 1. Petermann, E., Lan, L. & Zou, L. Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.Nat. Rev. Mol. Cell Biol.23, 521–540 (2022) 2. Morin, G. B. The human telomere terminal tran...
The proper regulation of transcription is essential for maintaining genome integrity and executing other downstream cellular functions1,2. Here we identify a stable association between the genome-stability regulator sensor of single-stranded DNA (SOSS)3
An R-loop is a nucleic acid structure consisting of two antiparallel DNA strands plus one RNA strand. From:Encyclopedia of Genetics,2001 Discover other topics Chapters and Articles You might find these chapters and articles relevant to this topic. ...
b, Zoomed-in view of the R-loop in the 6-nt match complex. c, Zoomed-in view of the R-loop in the 8-nt match complex. d, Zoomed-in view of the R-loop in the 10-nt match complex. e, Zoomed-in view of the interaction between the REC2 domain DDD helix and the REC3 RRR ...
RouterA上配置了Loopback1接口并为其配置IP地址。 为了节省IP地址资源,用户希望不为RouterA的Serial1/0/0接口配置IP地址,但又能实现正常通信。 图24-2 配置Loopback接口地址作为被借用地址组网图 配置思路 采用如下的思路配置RouterA: 配置RouterA的Serial接口借用Loopback1接口的IP地址,实现RouterA与RouterB的...
D. R-loop结构的形成会影响遗传信息的表达 答案：C 解析：解析:R-loop结构中杂合链之间的碱基对通过氢键连接,A正确;DNA双链中嘌呤碱基总数与嘧啶碱基总数是相等的,但是R-loop中嘌呤碱基总数与嘧啶碱基总数不一定相等,B正确;R-loop结构中的DNA单链为模板链的互补链,不能转录形成mRNA,C错误;由于新产生的mRNA与...
为保证Hub and Spoke组网方式中路由能够正确传递,从Hub-CE发布私网路由到Spoke-CE途中经过的相关BGP对等体需要配置允许AS_Path中AS号重复1次的路由通过。 前置条件 配置本命令前,需要先使用peer as-number命令建立相应的对等体关系。 注意事项 对于同一个对等体或对等体组,该命令是覆盖式的,后一次配置会覆盖前一次...
Data acquisition and processing Three single-cell RNA-seq (scRNA-seq) datasets of patients with LUAD and associated clinical information were collected from the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/: GSE123904, GSE131907, and GSE146100). Moreover, an indep...
4. Cristini, A. et al. Dual processing of R-loops and topoisomerase I induces transcription dependent DNA double-strand breaks.Cell Rep.28, 3167–3181 (2019) 5. Crossley, M. P. et al. Catalytically-inactive, purified RNaseH1: a specific an...