此外，G34R/V突变对于肿瘤的维持是非必需的，而突变的PDGFRA才是潜在的致癌驱动因子。总的来说，研究从基因组、表观遗传组和转录组绘制了致命性肿瘤脑胶质瘤的组学图谱，并揭示出G34R/V基因突变导致中间神经元祖细胞分化停滞，其与PDGFRA激活突变的共同作用促进恶性胶质瘤的发生，提示PDGFRA或是靶向治疗脑胶质瘤的...
然而,由于结直肠癌通常具有二倍体或近二倍体DNA含量并伴有少量染色体变异,MMRD结直肠癌通常不存在TP53失活突变和染色体不稳定。本研究中的MMRD IDH野生型和IDH突变型HGG大多有TP53、NF1、PIK3CA其他致病性错义突变、CDKN2A/2B缺失或突变、PDGFRA扩增或突变。此外,各种...
本研究根据Rspo2表达定义了Tppp3+Pdgfra+细胞的独特未分化祖细胞亚群。Rspo2与Prg4在小鼠跟腱Tppp3+Pdgfra+祖细胞中共表达。Prg4+细胞中的Rspo2过表达抑制了小鼠跟腱的异位骨化。同样,RSPO2抑制了人类韧带细胞的软骨分化,其表达在OPLL...
5156 (Human); 18595 (Mouse) Alternate Names alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; EC 2.7.10.1; MGC74795; PDGF R alpha; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA/BCR fusion; PDGF-R-alpha; platelet-derived...
CD140a, PDGFR alpha, PDGFRA Entrez Gene IDs 5156 (Human); 18595 (Mouse) Gene Symbol PDGFRA Additional PDGF R alpha Products All Products for PDGF R alpha PDGF R alpha cDNA Clones PDGF R alpha ELISA Kits PDGF R alpha Lysates PDGF R alpha Pr...
为更好地造福患者,向具有PDGFRA外显子18突变(包括PDGFRAD842V突变)的不可手术切除或转移性胃肠间质瘤(GIST)成人患者提供检测支持,给予患者关爱。 患者在近期入组成为项目会员,提交符合项目规定的材料,可免费获得一份基因检测福利,在满足理赔申请条件的情况下,可获得500元理赔。
Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 产品信息订购: 产品货号 产品名称 规格 价格 大包装及货期 abs04525 Recombinant Mouse PDGF R α/PDGFRA/CD140a (C-Fc) 10ug 838.00 立即咨询 abs04525 Recombinant Mouse PDGF R α/...
[3] Verhaak RG, et al."Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1."Cancer Cell 2010, 17:98-110. [1] https://www.genepattern.org/modules/docs/ABSOLUTE/2 ...
5156 (Human); 18595 (Mouse) Alternate Names alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; EC 2.7.10.1; MGC74795; PDGF R alpha; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA/BCR fusion; PDGF-R-alpha; platelet-derived...
PDGF-B PDGF-C PDGF-D PDGF-R PDGF-R-alpha PDGF-R-beta PDGF1 PDGF2 PDGFA PDGFA PDGFA-Associated Protein 1 PDGFB PDGFB PDGFB PDGFC PDGFC PDGFD PDGFD PDGFR PDGFR PDGFR-1 PDGFR-2 PDGFR-alpha PDGFR-beta PDGFR1 PDGFR2 PDGFRA PDGFRA PDGFRA/BCR fusion PDGFRB PDGFRB PDGFRL PDGG PDGI ▼Co...